CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA (guanine(10)-N2)-methyltransferase homolog 
Protein Synonyms/Alias
 tRNA guanosine-2'-O-methyltransferase TRM11 homolog 
Gene Name
 TRMT11 
Gene Synonyms/Alias
 C6orf75; MDS024 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139EFLPFEGKVNLKKPQubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MALSCTLNRY LLLMAQEHLE FRLPEIKSLL LLFGGQFASS QETYGKSPFW ILSIPSEDIA 60
RNLMKRTVCA KSIFELWGHG QSPEELYSSL KNYPVEKMVP FLHSDSTYKI KIHTFNKTLT 120
QEEKIKRIDA LEFLPFEGKV NLKKPQHVFS VLEDYGLDPN CIPENPHNIY FGRWIADGQR 180
ELIESYSVKK RHFIGNTSMD AGLSFIMANH GKVKENDIVF DPFVGTGGLL IACAHFGAYV 240
YGTDIDYNTV HGLGKATRKN QKWRGPDENI RANLRQYGLE KYYLDVLVSD ASKPSWRKGT 300
YFDAIITDPP YGIRESTRRT GSQKEIPKGI EKWEKCPESH VPVSLSYHLS DMFLDLLNFA 360
AETLVLGGRL VYWLPVYTPE YTEEMVPWHP CLELVSNCEQ KLSSHTSRRL ITMEKNRDQY 420
SHLLSDHFLP YQGHNSFREK YFSGVTKRIA KEEKSTQE 458 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR002052; DNA_methylase_N6_adenine_CS.
 IPR002296; N12N6_MeTrfase.
 IPR000241; RNA_methylase_dom.
 IPR016691; tRNA_mtfrase_TRM11. 
Pfam
 PF01170; UPF0020 
SMART
  
PROSITE
 PS00092; N6_MTASE 
PRINTS
 PR00507; N12N6MTFRASE.