UniProt Accession

 LYPA2_MOUSE; Q9WTL7; Q3TJD6 

Genbank Protein ID

 AB009653; AK003689; AK075590; AK089112; AK167478; BC068120 

Genbank Nucleotide ID

 BAA76751.1; BAB22940.1; BAC35841.1; BAC40757.1; BAE39559.1; AAH68120.1 

Protein Name

 Acyl-protein thioesterase 2 

Protein Synonyms/Alias

 APT-2; Lysophospholipase 2; Lysophospholipase II; LPL-II; LysoPLA II; mLyso II 

Gene Name

 Lypla2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
53	TIRLPHVKYICPHAP	acetylation	[1]
108	ALIEHEMKNGIPANR	acetylation	[2]
203	TPARVQFKTYPGVMH	ubiquitination	[3]
226	AVKEFLEKLLPPV**	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Deacylates GAP43 (By similarity). Has lysophospholipase activity. 

Sequence Annotation

 ACT_SITE 122 122 Charge relay system (By similarity).
 ACT_SITE 176 176 Charge relay system (By similarity).
 ACT_SITE 210 210 Charge relay system (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid metabolism; Hydrolase; Lipid metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR003140; PLipase/COase/thioEstase. 

Pfam

 PF02230; Abhydrolase_2 

SMART

  

PROSITE

  

PRINTS