| Tag | Content |
|---|
| CPLM ID | CPLM-013089 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Brain-specific angiogenesis inhibitor 1 |
Protein Synonyms/Alias | |
Gene Name | Bai1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1239 | ACRSVLNKDIAACRT | ubiquitination | [1] | | 1268 | EEKMKLAKGPPPTFN | ubiquitination | [1] | | 1308 | PNHSLTLKKDKAPKS | ubiquitination | [1] | | 1314 | LKKDKAPKSSFIGDG | ubiquitination | [1] | | 1325 | IGDGDIFKKLDSELS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain (By similarity). |
Sequence Annotation | DOMAIN 261 315 TSP type-1 1.
DOMAIN 354 407 TSP type-1 2.
DOMAIN 409 462 TSP type-1 3.
DOMAIN 467 520 TSP type-1 4.
DOMAIN 522 575 TSP type-1 5.
DOMAIN 881 938 GPS.
MOTIF 231 233 Cell attachment site (Potential).
MOD_RES 1276 1276 Phosphoserine.
MOD_RES 1467 1467 Phosphoserine.
CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
CARBOHYD 401 401 N-linked (GlcNAc...) (Potential).
CARBOHYD 607 607 N-linked (GlcNAc...) (Potential).
CARBOHYD 692 692 N-linked (GlcNAc...) (Potential).
CARBOHYD 844 844 N-linked (GlcNAc...) (Potential).
CARBOHYD 877 877 N-linked (GlcNAc...) (Potential).
CARBOHYD 881 881 N-linked (GlcNAc...) (Potential).
DISULFID 273 309 By similarity.
DISULFID 277 314 By similarity.
DISULFID 288 299 By similarity.
DISULFID 366 400 By similarity.
DISULFID 370 406 By similarity.
DISULFID 381 390 By similarity.
DISULFID 421 456 By similarity.
DISULFID 425 461 By similarity.
DISULFID 436 446 By similarity.
DISULFID 479 514 By similarity.
DISULFID 483 519 By similarity.
DISULFID 494 504 By similarity.
DISULFID 534 569 By similarity.
DISULFID 538 574 By similarity.
DISULFID 549 559 By similarity.
DISULFID 581 616 By similarity.
DISULFID 604 634 By similarity.
DISULFID 884 921 By similarity.
DISULFID 909 923 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1582 AA |
Protein Sequence | MRGQAAAPGP IWILAPLLLL LLLLGRWARA ASGADIGPGT EQCTTLVQGK FFGYFSAAAV 60
FPANASRCSW TLRNPDPRRY TLYMKVAKAP APCSGPGRVR TYQFDSFLES TRTYLGVESF 120
DEVLRLCDSS APLAFLQASK QFLQMQRQQP PQDGDLGPQG EFPSSSDDFS VEYLVVGNRN 180
PSHAACQMLC RWLDACLAGS RSSHPCGIMQ TPCACLGGDV GDPASSPLVP RGDVCLRDGV 240
AGGPENCLTS LTQDRGGHGS AGGWKLWSLW GECTRDCGGG LQTRTRTCLP TLGVEGGGCE 300
GVLEEGRLCN RKACGPTGRS SSRSQSLRST DARRREEFGD ELQQFGFPSP QTGDPAAEEW 360
SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC NNSAVCPVHG AWDEWSPWSL 420
CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE KQTKFCNIAL CPGRAVDGNW NEWSSWSTCS 480
ASCSQGRQQR TRECNGPSYG GAECQGHWVE TRDCFLQQCP VDGKWQAWAS WGSCSVTCGG 540
GSQRRERVCS GPFFGGAACQ GPQDEYRQCG AQRCPEPHEI CDEDNFGAVV WKETPAGEVA 600
AVRCPRNATG LILRRCELDE EGIAFWEPPT YIRCVSIDYR NIQMMTREHL AKAQRGLPGE 660
GVSEVIQTLL EISQDGTSYS GDLLSTIDVL RNMTEIFRRA YYSPTPGDVQ NFVQIISNLL 720
AEENRDKWEE AQLMGPNAKE LFRLVEDFVD VIGFRMKDLR DAYQVTDNLV LSIHKLPASG 780
ATDISFPMKG WRATGDWAKV PEDRVTVSKS VFSTGLAEAD DSSVFVVGTV LYRNLGSFLA 840
LQRNTTVLNS KVISVTVKPP PRSLLTPLEI EFAHMYNGTT NQTCILWDET DGPSSSAPPQ 900
LGPWSWRGCR TVPLDALRTR CLCDRLSTFA ILAQLSADAT MDKVTVPSVT LIVGCGVSSL 960
TLLMLVIIYV SVWRYIRSER SVILINFCLS IISSNALILI GQTQTRNKVV CTLVAAFLHF 1020
FFLSSFCWVL TEAWQSYMAV TGRLRSRLVR KRFLCLGWGL PALVVAISVG FTKAKGYSTM 1080
NYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSK DGITDKKLKE RAGASLWSSC 1140
VVLPLLALTW MSAVLAVTDR RSALFQILFA VFDSLEGFVI VMVHCILRRE VQDAVKCRVV 1200
DRQEEGNGDS GGSFQNGHAQ LMTDFEKDVD LACRSVLNKD IAACRTATIT GTFKRPSLPE 1260
EEKMKLAKGP PPTFNSLPAN VSKLHLHGSP RYPGGPLPDF PNHSLTLKKD KAPKSSFIGD 1320
GDIFKKLDSE LSRAQEKALD TSYVILPTAT ATLRPKPKEE PKYSINIDQM PQTRLIHLSM 1380
APDASFPTRS PPAREPPGGA PPEVPPVQPP PPPPPPPPPP QQPIPPPPTL EPAPPSLGDT 1440
GEPAAHPGPS SGAGAKNENV ATLSVSSLER RKSRYAELDF EKIMHTRKRH QDMFQDLNRK 1500
LQHAAEKEKE VPGADSKPEK QQTPNKRAWE SLRKPHGTPA WVKKELEPLP PSPLELRSVE 1560
WEKAGATIPL VGQDIIDLQT EV 1582 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004930; F:G-protein coupled receptor activity; IEA:InterPro. GO:0016525; P:negative regulation of angiogenesis; ISO:MGI. GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |