CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018396
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal large subunit pseudouridine synthase F 
Protein Synonyms/Alias
 23S rRNA pseudouridine(2604) synthase; rRNA pseudouridylate synthase F; rRNA-uridine isomerase F 
Gene Name
 rluF 
Gene Synonyms/Alias
 STM4193 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
269AIEKSNEKARPTSSGacetylation[1]
277ARPTSSGKRFTSPGRacetylation[1]
285RFTSPGRKKKGR***acetylation[1]
286FTSPGRKKKGR****acetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Responsible for synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA (By similarity). 
Sequence Annotation
 DOMAIN 7 74 S4 RNA-binding.
 REGION 105 108 Interaction with RNA (By similarity).
 REGION 187 190 Interaction with RNA (By similarity).
 ACT_SITE 107 107 Nucleophile (By similarity).  
Keyword
 Complete proteome; Isomerase; Reference proteome; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 289 AA 
Protein Sequence
MLTDTSTRLN KYISESGICS RREADRFIEQ GNVFINGKRA AIGDQVVAGD IVKVNGRLIE 60
PREADDLVLI ALNKPVGIVS TTEDGERDNI VDFVNHSKRI FPIGRLDKDS QGLIFLTNHG 120
DLVNKILRAG NDHEKEYLVT VDKPITDEFI RGMGAGVPIL GTVTKKCKVK KEAPFVFRIT 180
LVQGLNRQIR RMCEYFGYEV TKLERTRIMN VSLSGIPLGE WRDLTDDELI DLFKLIERSS 240
SEAKPKAKAK PKTTGIKRPV VAIEKSNEKA RPTSSGKRFT SPGRKKKGR 289 
Gene Ontology
 GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR020103; PsdUridine_synth_cat_dom.
 IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
 IPR018496; PsdUridine_synth_RsuA/RluB_CS.
 IPR006145; PsdUridine_synth_RsuA/RluD.
 IPR002942; S4_RNA-bd. 
Pfam
 PF00849; PseudoU_synth_2
 PF01479; S4 
SMART
 SM00363; S4 
PROSITE
 PS01149; PSI_RSU
 PS50889; S4 
PRINTS