UniProt Accession

 KRA59_HUMAN; P26371; Q14564; Q3MIP8 

Genbank Protein ID

 X55293; AJ006693; X63755; AB126078; BC069531; BC101744 

Genbank Nucleotide ID

 CAA39005.1; CAA07189.1; CAA45283.1; BAD20205.1; AAH69531.1; AAI01745.2 

Protein Name

 Keratin-associated protein 5-9 

Protein Synonyms/Alias

 Keratin, cuticle, ultrahigh sulfur 1; Keratin, ultra high-sulfur matrix protein A; Keratin-associated protein 5.9; UHS keratin A; UHS KerA; Ultrahigh sulfur keratin-associated protein 5.9 

Gene Name

 KRTAP5-9 

Gene Synonyms/Alias

 KAP5.9; KRN1; KRTAP5.9; UHSK1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
113	CSQCSCCKPCCSSSG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. 

Sequence Annotation

 REPEAT 35 38 1.
 REPEAT 41 44 2.
 REPEAT 47 50 3.
 REPEAT 82 85 4.
 REPEAT 101 104 5.
 REPEAT 130 134 6.
 REPEAT 149 152 7.
 REPEAT 159 162 8.
 REGION 35 162 8 X 4 AA repeats of C-C-X-P.  

Keyword

 Complete proteome; Keratin; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0008544; P:epidermis development; TAS:ProtInc. 

Interpro

 IPR002494; Keratin-assoc. 

Pfam

  

SMART

  

PROSITE

  

PRINTS