UniProt Accession

 AP1M2_HUMAN; Q9Y6Q5; B2RDV5; Q9BSI8 

Genbank Protein ID

 AF020797; AK315689; CH471106; BC003387; BC003612; BC005021 

Genbank Nucleotide ID

 AAD25870.2; BAG38052.1; EAW84124.1; AAH03387.1; AAH03612.1; AAH05021.1 

Protein Name

 AP-1 complex subunit mu-2 

Protein Synonyms/Alias

 AP-mu chain family member mu1B; Adaptor protein complex AP-1 mu-2 subunit; Adaptor-related protein complex 1 mu-2 subunit; Clathrin assembly protein complex 1 medium chain 2; Golgi adaptor HA1/AP1 adaptin mu-2 subunit; Mu-adaptin 2; Mu1B-adaptin 

Gene Name

 AP1M2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	PLISRNYKGDVAMSK	ubiquitination	[1]
29	KGDVAMSKIEHFMPL	ubiquitination	[1]
141	YITQQSNKLETGKSR	ubiquitination	[1]
146	SNKLETGKSRVPPTV	ubiquitination	[1]
229	LTGLSGSKNKSVELE	ubiquitination	[1, 2]
231	GLSGSKNKSVELEDV	ubiquitination	[1]
276	YRLSTQVKPLIWIES	ubiquitination	[1]
305	KAKGQFKKQSVANGV	ubiquitination	[1]
335	KTSVGSAKYVPERNV	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. 

Sequence Annotation

 DOMAIN 168 421 MHD.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005765; C:lysosomal membrane; TAS:Reactome.
 GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0006605; P:protein targeting; TAS:ProtInc.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0006903; P:vesicle targeting; TAS:ProtInc.
 GO:0016032; P:viral reproduction; TAS:Reactome. 

Interpro

 IPR022775; AP_mu_sigma_su.
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 

PRINTS

 PR00314; CLATHRINADPT.