UniProt Accession

 STIM1_RAT; P84903 

Genbank Protein ID

 AABR03000423; AABR03002698 

Genbank Nucleotide ID

  

Protein Name

 Stromal interaction molecule 1 

Protein Synonyms/Alias

  

Gene Name

 Stim1 

Gene Synonyms/Alias

 Sim 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
377	ERQLLVAKEGAEKIK	acetylation	[1]
650	RIPHLAGKKAMAEED	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. 

Sequence Annotation

 DOMAIN 63 98 EF-hand.
 DOMAIN 132 190 SAM.
 REGION 334 444 SOAR/CAD (By similarity).
 MOTIF 642 645 Microtubule tip localization signal.
 MOD_RES 257 257 Phosphoserine (By similarity).
 MOD_RES 519 519 Phosphoserine (By similarity).
 MOD_RES 524 524 Phosphoserine (By similarity).
 MOD_RES 575 575 Phosphoserine (By similarity).
 MOD_RES 608 608 Phosphoserine (By similarity).
 MOD_RES 660 660 Phosphoserine (By similarity).
 MOD_RES 665 665 Phosphothreonine (By similarity).
 MOD_RES 668 668 Phosphoserine (By similarity).
 CARBOHYD 131 131 N-linked (GlcNAc...) (Potential).
 CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).  

Keyword

 Calcium; Calcium transport; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Glycoprotein; Ion transport; Membrane; Metal-binding; Microtubule; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 685 AA 

Protein Sequence

Gene Ontology

 GO:0032541; C:cortical endoplasmic reticulum; IEA:Compara.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005246; F:calcium channel regulator activity; IMP:RGD.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0051010; F:microtubule plus-end binding; ISS:UniProtKB.
 GO:0015279; F:store-operated calcium channel activity; IMP:RGD.
 GO:0032237; P:activation of store-operated calcium channel activity; ISS:UniProtKB.
 GO:0005513; P:detection of calcium ion; ISS:UniProtKB.
 GO:2001256; P:regulation of store-operated calcium entry; IMP:RGD.
 GO:0002115; P:store-operated calcium entry; IMP:RGD. 

Interpro

 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2. 

Pfam

 PF07647; SAM_2 

SMART

 SM00454; SAM 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50105; SAM_DOMAIN 

PRINTS