UniProt Accession

 SARNP_MOUSE; Q9D1J3; Q3UJZ4; Q9CU18 

Genbank Protein ID

 AK003453; AK018773; AK088266; AK146248; BC027510 

Genbank Nucleotide ID

 BAB22799.1; BAB31400.1; BAC40246.1; BAE27010.1; AAH27510.1 

Protein Name

 SAP domain-containing ribonucleoprotein 

Protein Synonyms/Alias

 Nuclear protein Hcc-1 

Gene Name

 Sarnp 

Gene Synonyms/Alias

 Hcc1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
10	AETVELHKLKLAELK	acetylation	[1, 2, 3]
10	AETVELHKLKLAELK	ubiquitination	[4]
12	TVELHKLKLAELKQE	acetylation	[1]
17	KLKLAELKQECLARG	acetylation	[1]
31	GLETKGIKQDLINRL	acetylation	[1]
92	ASEKKVVKITSGIPQ	acetylation	[1]
119	VPVSLESKKAARAAR	acetylation	[2]
142	KGLSSDTKPMVNLDK	acetylation	[1, 2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis (By similarity). 

Sequence Annotation

 DOMAIN 8 42 SAP.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 163 163 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003034; SAP_dom. 

Pfam

 PF02037; SAP 

SMART

 SM00513; SAP 

PROSITE

 PS50800; SAP 

PRINTS