CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018421
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarate hydratase class II 
Protein Synonyms/Alias
 Fumarase C 
Gene Name
 fumC 
Gene Synonyms/Alias
 STM1469 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
127GVRGMERKVHPNDDVacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the reversible addition of water to fumarate to give L-malate (By similarity). 
Sequence Annotation
 REGION 98 100 Substrate binding (By similarity).
 REGION 129 132 B site (By similarity).
 REGION 139 141 Substrate binding (By similarity).
 REGION 187 188 Substrate binding (By similarity).
 REGION 324 326 Substrate binding (By similarity).
 ACT_SITE 188 188 Proton donor/acceptor (By similarity).
 ACT_SITE 318 318 By similarity.
 BINDING 319 319 Substrate (By similarity).  
Keyword
 Allosteric enzyme; Complete proteome; Cytoplasm; Lyase; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 467 AA 
Protein Sequence
MVTVRREKDS MGAIEVPADK LWGAQTQRSL EHFRISTEKM PVSLIHALAL TKRAAAKVNQ 60
DLGLLAAEKA SAIIQAADEV LAGKHADEFP LAIWQTGSGT QSNMNMNEVL ANRASEILGG 120
VRGMERKVHP NDDVNKSQSS NDVFPTAMHV AALLALREHL IPQLSALTDT LRDKSHAFAD 180
IVKIGRTHLQ DATPLTLGQE ISGWVAMLEH NLRHIEHSLP HVAELALGGT AVGTGLNTHP 240
EYARRVAEEL ATITAAPFVT APNKFEALAT CDALVQAHGA LKGLAASLMK IANDVRWLAS 300
GPRCGIGEIA IPENEPGSSI MPGKVNPTQC EAVTMLCCQV MGNDVAINMG GASGNFELNV 360
YRPMVIHNFL QTVRLLADGM ESFNKHCASG IEPNRERITQ LLNESLMLVT ALNTHIGYDK 420
AAEIAKKAHK EGLTLKASAV ALGYLSDEEF DAWVRPELMV GSMTPGR 467 
Gene Ontology
 GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
 GO:0004333; F:fumarate hydratase activity; IEA:HAMAP.
 GO:0006106; P:fumarate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP. 
Interpro
 IPR003031; D_crystallin.
 IPR005677; Fum_hydII.
 IPR024083; Fumarase/histidase_N.
 IPR018951; Fumarase_C_C.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like. 
Pfam
 PF10415; FumaraseC_C
 PF00206; Lyase_1 
SMART
  
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.