CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004080
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-CoA desaturase 2 
Protein Synonyms/Alias
 Delta(9)-desaturase 2; Delta-9 desaturase 2; Fatty acid desaturase 2; Stearoyl-CoA desaturase 2 
Gene Name
 Scd2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
161RDHRAHHKFSETHADubiquitination[1]
198AVKEKGGKLDMSDLKubiquitination[1]
205KLDMSDLKAEKLVMFacetylation[2]
205KLDMSDLKAEKLVMFubiquitination[1]
208MSDLKAEKLVMFQRRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
 Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. 
Sequence Annotation
 MOTIF 119 124 Histidine box-1.
 MOTIF 156 160 Histidine box-2.
 MOTIF 297 301 Histidine box-3.  
Keyword
 Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Iron; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MPAHILQEIS GAYSATTTIT APPSGGQQNG GEKFEKSSHH WGADVRPELK DDLYDPTYQD 60
DEGPPPKLEY VWRNIILMAL LHLGALYGIT LVPSCKLYTC LFAYLYYVIS ALGITAGAHR 120
LWSHRTYKAR LPLRLFLIIA NTMAFQNDVY EWARDHRAHH KFSETHADPH NSRRGFFFSH 180
VGWLLVRKHP AVKEKGGKLD MSDLKAEKLV MFQRRYYKPG LLLMCFVLPT LVPWYCWGET 240
FVNSLCVSTF LRYAVVLNAT WLVNSAAHLY GYRPYDKNIS SRENILVSMG AVGEGFHNYH 300
HAFPYDYSAS EYRWHINFTT FFIDCMALLG LAYDRKRVSR AAVLARIKRT GDGSCKSG 358 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004768; F:stearoyl-CoA 9-desaturase activity; IEA:EC.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR005804; Fatty_acid_desaturase-1.
 IPR001522; Fatty_acid_desaturase-1_C.
 IPR015876; Fatty_acid_desaturase-1_core. 
Pfam
 PF00487; FA_desaturase 
SMART
  
PROSITE
 PS00476; FATTY_ACID_DESATUR_1 
PRINTS
 PR00075; FACDDSATRASE.