| Tag | Content |
|---|
| CPLM ID | CPLM-001380 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Voltage-dependent calcium channel gamma-2 subunit |
Protein Synonyms/Alias | Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2 |
Gene Name | Cacng2 |
Gene Synonyms/Alias | Stg |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 305 | QVHNCIQKDSKDSLH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). |
Sequence Annotation | MOD_RES 253 253 Phosphoserine.
MOD_RES 271 271 Phosphotyrosine.
MOD_RES 321 321 Phosphothreonine; by PKA.
CARBOHYD 48 48 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Calcium channel; Calcium transport; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 323 AA |
Protein Sequence | MGLFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KTKSVSENET SKKNEEVMTH 60
SGLWRTCCLE GNFKGLCKQI DHFPEDADYE ADTAEYFLRA VRASSIFPIL SVILLFMGGL 120
CIAASEFYKT RHNIILSAGI FFVSAGLSNI IGIIVYISAN AGDPSKSDSK KNSYSYGWSF 180
YFGALSFIIA EMVGVLAVHM FIDRHKQLRA TARATDYLQA SAITRIPSYR YRYQRRSRSS 240
SRSTEPSHSR DASPVGVKGF NTLPSTEISM YTLSRDPLKA ATTPTATYNS DRDNSFLQVH 300
NCIQKDSKDS LHANTANRRT TPV 323 |
Gene Ontology | GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:UniProtKB. GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro. GO:0005245; F:voltage-gated calcium channel activity; IMP:MGI. GO:0051899; P:membrane depolarization; IMP:MGI. GO:0060081; P:membrane hyperpolarization; IMP:MGI. GO:0007528; P:neuromuscular junction development; IMP:MGI. GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB. GO:0019226; P:transmission of nerve impulse; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |