| Tag | Content |
|---|
| CPLM ID | CPLM-018923 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | P2X purinoceptor 5 |
Protein Synonyms/Alias | P2X5; ATP receptor; Purinergic receptor |
Gene Name | P2RX5 |
Gene Synonyms/Alias | P2X5 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | VTAGNGVKTGRCLRR | ubiquitination | [1] | | 193 | EDFTIFIKNHIRFPK | ubiquitination | [1] | | 217 | VKDRSFLKSCHFGPK | ubiquitination | [1] | | 286 | RLDNKLSKSVSSGYN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Receptor for ATP that acts as a ligand-gated ion channel. |
Sequence Annotation | CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
CARBOHYD 202 202 N-linked (GlcNAc...) (Potential).
DISULFID 118 169 By similarity.
DISULFID 129 152 By similarity.
DISULFID 135 163 By similarity.
DISULFID 220 229 By similarity.
DISULFID 263 272 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 422 AA |
Protein Sequence | MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL IKKGYQDVDT 60
SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV FFVVTNLIVT PNQRQNVCAE 120
NEGIPDGACS KDSDCHAGEA VTAGNGVKTG RCLRRENLAR GTCEIFAWCP LETSSRPEEP 180
FLKEAEDFTI FIKNHIRFPK FNFSNNVMDV KDRSFLKSCH FGPKNHYCPI FRLGSVIRWA 240
GSDFQDIALE GGVIGINIEW NCDLDKAASE CHPHYSFSRL DNKLSKSVSS GYNFRFARYY 300
RDAAGVEFRT LMKAYGIRFD VMVNGKGAFF CDLVLIYLIK KREFYRDKKY EEVRGLEDSS 360
QEAEDEASGL GLSEQLTSGP GLLGMPEQQE LQEPPEAKRG SSSQKGNGSV CPQLLEPHRS 420
T 421 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005524; F:ATP binding; NAS:BHF-UCL. GO:0004931; F:extracellular ATP-gated cation channel activity; NAS:BHF-UCL. GO:0001614; F:purinergic nucleotide receptor activity; NAS:BHF-UCL. GO:0007399; P:nervous system development; TAS:ProtInc. GO:0010524; P:positive regulation of calcium ion transport into cytosol; NAS:BHF-UCL. GO:0050850; P:positive regulation of calcium-mediated signaling; NAS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |