CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021584
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Arginyl aminopeptidase-like 1 
Protein Synonyms/Alias
 RNPEP-like 1 
Gene Name
 RNPEPL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
191GEDSPVSKLQVKLEPubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 REGION 95 99 Substrate binding (By similarity).
 ACT_SITE 123 123 Proton acceptor (By similarity).
 METAL 122 122 Zinc; catalytic (By similarity).
 METAL 126 126 Zinc; catalytic (By similarity).
 METAL 145 145 Zinc; catalytic (By similarity).  
Keyword
 Aminopeptidase; Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 494 AA 
Protein Sequence
MSATRSAYME EEGVFHFHME HPVPAYLVAL VAGDLKPADI GPRSRVWAEP CLLPTATSKL 60
SGAVEQWLSA AERLYGPYMW GRYDIVFLPP SFPIVAMENP CLTFIISSIL ESDEFLVIDV 120
IHEVAHSWFG NAVTNATWEE MWLSEGLATY AQRRITTETY GAAFTCLETA FRLDALHRQM 180
KLLGEDSPVS KLQVKLEPGV NPSHLMNLFT YEKGYCFVYY LSQLCGDPQR FDDFLRAYVE 240
KYKFTSVVAQ DLLDSFLSFF PELKEQSVDC RAGLEFERWL NATGPPLAEP DLSQGSSLTR 300
PVEALFQLWT AEPLDQAAAS ASAIDISKWR TFQTALFLDR LLDGSPLPQE VVMSLSKCYS 360
SLLDSMNAEI RIRWLQIVVR NDYYPDLHRV RRFLESQMSR MYTIPLYEDL CTGALKSFAL 420
EVFYQTQGRL HPNLRRAIQQ ILSQGLGSST EPASEPSTEL GKAEADTDSD AQALLLGDEA 480
PSSAISLRDV NVSA 494 
Gene Ontology
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR016024; ARM-type_fold.
 IPR001930; Peptidase_M1.
 IPR015211; Peptidase_M1_C.
 IPR014782; Peptidase_M1_N. 
Pfam
 PF09127; Leuk-A4-hydro_C
 PF01433; Peptidase_M1 
SMART
  
PROSITE
 PS00142; ZINC_PROTEASE 
PRINTS
 PR00756; ALADIPTASE.