UniProt Accession

 LAP2A_MOUSE; Q61033; B2RUB9; Q61028 

Genbank Protein ID

 U39073; U39078; CH466539; BC141062 

Genbank Nucleotide ID

 AAC52573.1; AAC52578.1; EDL21530.1; AAI41063.1 

Protein Name

 Lamina-associated polypeptide 2, isoforms alpha/zeta 

Protein Synonyms/Alias

 Thymopoietin isoforms alpha/zeta; TP alpha/zeta 

Gene Name

 Tmpo 

Gene Synonyms/Alias

 Lap2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
655	GRRYLWLKDCKISPA	acetylation	[1]
673	KLTVAPFKGGTLFGG	acetylation	[1, 2]
684	LFGGEVHKVIKKRGN	acetylation	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1 (By similarity). 

Sequence Annotation

 DOMAIN 5 48 LEM-like.
 DOMAIN 108 152 LEM.
 REGION 49 107 Linker.
 MOTIF 190 196 Nuclear localization signal (Potential).
 MOD_RES 59 59 Phosphoserine (By similarity).
 MOD_RES 66 66 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine (By similarity).
 MOD_RES 74 74 Phosphothreonine (By similarity).
 MOD_RES 79 79 Phosphoserine (By similarity).
 MOD_RES 153 153 Phosphothreonine (By similarity).
 MOD_RES 155 155 Phosphoserine (By similarity).
 MOD_RES 159 159 Phosphothreonine.
 MOD_RES 163 163 Phosphothreonine.
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 349 349 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).
 MOD_RES 368 368 Phosphoserine (By similarity).
 MOD_RES 422 422 Phosphoserine.
 MOD_RES 655 655 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Chromosome; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 693 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; ISO:MGI.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0005637; C:nuclear inner membrane; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI. 

Interpro

 IPR021623; LAP2alpha.
 IPR013146; LEM-like_dom.
 IPR011015; LEM/LEM-like_dom.
 IPR003887; LEM_dom. 

Pfam

 PF11560; LAP2alpha
 PF03020; LEM
 PF08198; Thymopoietin 

SMART

 SM00540; LEM 

PROSITE

 PS50954; LEM
 PS50955; LEM_LIKE 

PRINTS