UniProt Accession

 K2C75_HUMAN; O95678; B4DQU4; Q9NSA9 

Genbank Protein ID

 Y17282; Y19212; AK298960; AC055736 

Genbank Nucleotide ID

 CAA76730.1; CAB76832.1; BAG61056.1 

Protein Name

 Keratin, type II cytoskeletal 75 

Protein Synonyms/Alias

 Cytokeratin-75; CK-75; Keratin-6 hair follicle; hK6hf; Keratin-75; K75; Type II keratin-K6hf; Type-II keratin Kb18 

Gene Name

 KRT75 

Gene Synonyms/Alias

 K6HF; KB18 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
154	AEEREQIKTLNNKFA	ubiquitination	[1]
159	QIKTLNNKFASFIDK	ubiquitination	[1]
166	KFASFIDKVRFLEQQ	acetylation	[2]
166	KFASFIDKVRFLEQQ	ubiquitination	[1]
407	QRGELALKDARAKLV	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. 

Sequence Annotation

 REGION 1 148 Head.
 REGION 149 458 Rod.
 REGION 149 184 Coil 1A.
 REGION 185 203 Linker 1.
 REGION 204 296 Coil 1B.
 REGION 297 319 Linker 12.
 REGION 320 458 Coil 2.
 REGION 459 551 Tail.
 MOD_RES 72 72 Phosphoserine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Disease mutation; Intermediate filament; Keratin; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 551 AA 

Protein Sequence

Gene Ontology

 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005198; F:structural molecule activity; TAS:ProtInc. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II.
 IPR009053; Prefoldin. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS

 PR01276; TYPE2KERATIN.