CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000606
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vesicular inhibitory amino acid transporter 
Protein Synonyms/Alias
 GABA and glycine transporter; Solute carrier family 32 member 1; Vesicular GABA transporter; mVGAT; mVIAAT 
Gene Name
 Slc32a1 
Gene Synonyms/Alias
 Vgat; Viaat 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
64GLQMDILKSEGEPCGubiquitination[1]
113GEFGGHDKPKITAWEubiquitination[1]
258LLPCAFLKNLKAVSKacetylation[2]
258LLPCAFLKNLKAVSKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Involved in the uptake of GABA and glycine into the synaptic vesicles. 
Sequence Annotation
 MOD_RES 186 186 Nitrated tyrosine.
 CARBOHYD 341 341 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Membrane; Neurotransmitter transport; Nitration; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 525 AA 
Protein Sequence
MATLLRSKLT NVATSVSNKS QAKVSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM 60
DILKSEGEPC GDEGAEAPVE GDIHYQRGGA PLPPSGSKDQ AVGAGGEFGG HDKPKITAWE 120
AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV 180
RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ 240
KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY 300
IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL 360
TWADETKEVI TDNLPGSIRA VVNLFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA 420
CYGGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL 480
LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED 525 
Gene Ontology
 GO:0051286; C:cell tip; IDA:MGI.
 GO:0044316; C:cone cell pedicle; IDA:MGI.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0044292; C:dendrite terminus; IDA:MGI.
 GO:0060077; C:inhibitory synapse; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IC:MGI.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0015495; F:gamma-aminobutyric acid:hydrogen symporter activity; IDA:MGI.
 GO:0015187; F:glycine transmembrane transporter activity; IDA:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW. 
Interpro
 IPR013057; AA_transpt_TM. 
Pfam
 PF01490; Aa_trans 
SMART
  
PROSITE
  
PRINTS