UniProt Accession

 NUDB_ECOLI; P0AFC0; P24236 

Genbank Protein ID

 X59551; D10165; U00096; AP009048 

Genbank Nucleotide ID

 CAA42124.1; BAA01029.1; AAC74935.1; BAA15676.1 

Protein Name

 Dihydroneopterin triphosphate pyrophosphatase 

Protein Synonyms/Alias

 dATP pyrophosphohydrolase 

Gene Name

 nudB 

Gene Synonyms/Alias

 ntpA; b1865; JW1854 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
122	FTEHLAYKWLDAPAA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. 

Sequence Annotation

 DOMAIN 5 146 Nudix hydrolase.
 REGION 81 84 Substrate binding (Potential).
 MOTIF 41 62 Nudix box.
 METAL 56 56 Magnesium.
 METAL 60 60 Magnesium.
 METAL 117 117 Magnesium.
 BINDING 7 7 Substrate.
 BINDING 29 29 Substrate.
 BINDING 40 40 Substrate.
 BINDING 135 135 Substrate (Potential).  

Keyword

 3D-structure; Complete proteome; Folate biosynthesis; Hydrolase; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0008828; F:dATP pyrophosphohydrolase activity; IDA:EcoCyc.
 GO:0019177; F:dihydroneopterin triphosphate pyrophosphohydrolase activity; IDA:EcoCyc.
 GO:0000287; F:magnesium ion binding; IDA:EcoCyc.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0046656; P:folic acid biosynthetic process; IMP:EcoCyc.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR003564; dATP_pyrPHydro.
 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS

 PR01404; NPPPHYDRLASE.