CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022267
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CUE domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 CUEDC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
228GDQESRWKQYLEDERubiquitination[1, 2, 3]
272KYESQKSKSSSVAVGubiquitination[2]
318MGKSTRRKLFELARAubiquitination[1, 3, 4]
342SKRKHLLKHQSLGAAubiquitination[1, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
 DOMAIN 46 89 CUE.
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 273 273 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 386 AA 
Protein Sequence
MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA MDDFKTMFPN 60
MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE DSSDSEDSIP PEILERTLEP 120
DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP TPPPRIDALG SGAPTSQRRY RNWNPPLLGN 180
LPDDFLRILP QQLDSIQGNA GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LEDERIALFL 240
QNEEFMKELQ RNRDFLLALE RDRLKYESQK SKSSSVAVGN DFGFSSPVPG TGDANPAVSE 300
DALFRDKLKH MGKSTRRKLF ELARAFSEKT KMRKSKRKHL LKHQSLGAAA STANLLDDVE 360
GHACDEDFRG RRQEAPKVEE GLREGQ 386 
Gene Ontology
  
Interpro
 IPR003892; CUE.
 IPR009060; UBA-like. 
Pfam
 PF02845; CUE 
SMART
 SM00546; CUE 
PROSITE
 PS51140; CUE 
PRINTS