CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037356
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 1-phosphatidylinositol 3-phosphate 5-kinase 
Protein Synonyms/Alias
  
Gene Name
 PIKFYVE 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
356LLDSVQLKDLWKKICubiquitination[1]
680LQEREFLKNYVQRIVubiquitination[1]
698PTLVLVEKTVSRIAQubiquitination[1]
882ELRIVFEKGEQENKNubiquitination[1]
1109RGGRIQPKNSDPFAHubiquitination[1]
1150SDAVWSTKVDCLNPIubiquitination[1]
1358VSLLQDLKDFFQKVSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1384 AA 
Protein Sequence
MATDDKTSPT LDSANDLPRS PTSPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERA 60
EGGQGEQQPL SGSWTSPQLP SRTQSVRSPT PYKKQLNEEL QRRSSALDTR RKAEPTFGGH 120
DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC 180
RLCGQIFCSR CCNQEIPGKF MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDSA 240
CSVSVLDPSE PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNTPLSTRLV SVQEDAGKSP 300
ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRTYVRTE TTEDERKILL DSVQLKDLWK 360
KICHHSSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI ATRAQAIAIG QAMVDGRWLD 420
CVSHHDQLFR DEYALYRPLQ STEFSETPSP DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI 480
AEEGDDNLAK YLISDTGGQQ LSISDAFIKE SLFNRRVEEK SKELPFTPLG WHHNNLELLR 540
EENGEKQAME RLLSANHNHM MALLQQLLHS DSLSSSWRDI IVSLVCQVVQ TVRPDVKNQD 600
DDMDIRQFVH IKKIPGGKKF DSVVVNGFVC TKNIAHKKMS SCIKNPKILL LKCSIEYLYR 660
EETKFTCIDP IVLQEREFLK NYVQRIVDVR PTLVLVEKTV SRIAQDMLLE HGITLVINVK 720
SQVLERISRM TQGDLVMSMD QLLTKPHLGT CHKFYMQIFQ LPNEQTKTLM FFEGCPQHLG 780
CTIKLRGGSD YELARVKEIL IFMICVAYHS QLEISFLMDE FAMPPTLMQN PSFHSLIEGR 840
GHEGAVQEQY GGGSIPWDPD IPPESLPCDD SSLLELRIVF EKGEQENKNL PQAVASVKHQ 900
EHSTTACPAG LPCAFFAPVP ESLLPLPVDD QQDALGSEQP ETLQQTVVLQ DPKSQIRAFR 960
DPLQDDTGLY VTEEVTSSED KRKTYSLAFK QELKDVILCI SPVITFREPF LLTEKGMRCS 1020
TRDYFAEQVY WSPLLNKEFK EMENRRKKQL LRDLSGLQGM NGSIQAKSIQ VLPSHELVST 1080
RIAEHLGDSQ SLGRMLADYR ARGGRIQPKN SDPFAHSKDA SSTSSGQSGS KNEGDEERGL 1140
ILSDAVWSTK VDCLNPINHQ RLCVLFSSSS AQSSNAPSAC VSPWIVTMEF YGKNDLTLGI 1200
FLERYCFRPS YQCPSMFCDT PMVHHIRRFV HGQGCVQIIL KELDSPVPGY QHTILTYSWC 1260
RICKQVTPVV ALSNESWSMS FAKYLELRFY GHQYTRRANA EPCGHSIHHD YHQYFSYNQM 1320
VASFSYSPIR LLEVCVPLPK IFIKRQAPLK VSLLQDLKDF FQKVSQVYVA IDERLASLKT 1380
DTFS 1384 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR002423; Cpn60/TCP-1.
 IPR000591; DEP_dom.
 IPR027409; GroEL-like_apical_dom.
 IPR027410; TCP-1-like_intermed.
 IPR011991; WHTH_DNA-bd_dom.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00118; Cpn60_TCP1
 PF00610; DEP
 PF01363; FYVE 
SMART
 SM00049; DEP
 SM00064; FYVE 
PROSITE
 PS50186; DEP
 PS50178; ZF_FYVE 
PRINTS