CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005596
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynamin 
Protein Synonyms/Alias
 Protein shibire; dDyn 
Gene Name
 shi 
Gene Synonyms/Alias
 CG18102 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
594PDGRNVYKDYKQLELacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting. 
Sequence Annotation
 DOMAIN 513 621 PH.
 DOMAIN 650 741 GED.
 NP_BIND 33 40 GTP (Potential).
 NP_BIND 131 135 GTP (Potential).
 NP_BIND 200 203 GTP (Potential).
 MOD_RES 756 756 Phosphoserine.
 MOD_RES 764 764 Phosphoserine.
 MOD_RES 767 767 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Endocytosis; GTP-binding; Hydrolase; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 877 AA 
Protein Sequence
MDSLITIVNK LQDAFTSLGV HMQLDLPQIA VVGGQSAGKS SVLENFVGKD FLPRGSGIVT 60
RRPLILQLIN GVTEYGEFLH IKGKKFSSFD EIRKEIEDET DRVTGSNKGI SNIPINLRVY 120
SPHVLNLTLI DLPGLTKVAI GDQPVDIEQQ IKQMIFQFIR KETCLILAVT PANTDLANSD 180
ALKLAKEVDP QGVRTIGVIT KLDLMDEGTD ARDILENKLL PLRRGYIGVV NRSQKDIEGR 240
KDIHQALAAE RKFFLSHPSY RHMADRLGTP YLQRVLNQQL TNHIRDTLPG LRDKLQKQML 300
TLEKEVEEFK HFQPGDASIK TKAMLQMIQQ LQSDFERTIE GSGSALVNTN ELSGGAKINR 360
IFHERLRFEI VKMACDEKEL RREISFAIRN IHGIRVGLFT PDMAFEAIVK RQIALLKEPV 420
IKCVDLVVQE LSVVVRMCTA KMSRYPRLRE ETERIITTHV RQREHSCKEQ ILLLIDFELA 480
YMNTNHEDFI GFANAQNKSE NANKTGTRQL GNQVIRKGHM VIQNLGIMKG GSRPYWFVLT 540
SESISWYKDE DEKEKKFMLP LDGLKLRDIE QGFMSMSRRV TFALFSPDGR NVYKDYKQLE 600
LSCETVEDVE SWKASFLRAG VYPEKQETQE NGDESASEES SSDPQLERQV ETIRNLVDSY 660
MKIVTKTTRD MVPKAIMMLI INNAKDFING ELLAHLYASG DQAQMMEESA ESATRREEML 720
RMYRACKDAL QIIGDVSMAT VSSPLPPPVK NDWLPSGLDN PRLSPPSPGG VRGKPGPPAQ 780
SSLGGRNPPL PPSTGRPAPA IPNRPGGGAP PLPGGRPGGS LPPPMLPSRV SGAVGGAIVQ 840
QSGANRYVPE SMRGQVNQAV GQAAINELSN AFSSRFK 877 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:FlyBase.
 GO:0070864; C:sperm individualization complex; IDA:FlyBase.
 GO:0045202; C:synapse; IMP:FlyBase.
 GO:0003779; F:actin binding; IDA:FlyBase.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; NAS:FlyBase.
 GO:0008017; F:microtubule binding; IDA:FlyBase.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0034334; P:adherens junction maintenance; IMP:FlyBase.
 GO:0007298; P:border follicle cell migration; IMP:FlyBase.
 GO:0046667; P:compound eye retinal cell programmed cell death; IMP:FlyBase.
 GO:0001661; P:conditioned taste aversion; IMP:FlyBase.
 GO:0030866; P:cortical actin cytoskeleton organization; IMP:FlyBase.
 GO:0000910; P:cytokinesis; IMP:FlyBase.
 GO:0007427; P:epithelial cell migration, open tracheal system; IMP:FlyBase.
 GO:0030198; P:extracellular matrix organization; IMP:FlyBase.
 GO:0030536; P:larval feeding behavior; IMP:FlyBase.
 GO:0001738; P:morphogenesis of a polarized epithelium; IMP:FlyBase.
 GO:0008355; P:olfactory learning; IDA:FlyBase.
 GO:0007279; P:pole cell formation; TAS:FlyBase.
 GO:0045747; P:positive regulation of Notch signaling pathway; IMP:FlyBase.
 GO:0007637; P:proboscis extension reflex; IMP:FlyBase.
 GO:0006898; P:receptor-mediated endocytosis; NAS:FlyBase.
 GO:0032956; P:regulation of actin cytoskeleton organization; IGI:FlyBase.
 GO:0040008; P:regulation of growth; IMP:FlyBase.
 GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IMP:FlyBase.
 GO:0050803; P:regulation of synapse structure and activity; IMP:FlyBase.
 GO:0035152; P:regulation of tube architecture, open tracheal system; IMP:FlyBase.
 GO:0009408; P:response to heat; IMP:FlyBase.
 GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
 GO:0007614; P:short-term memory; IMP:FlyBase.
 GO:0007291; P:sperm individualization; IMP:FlyBase.
 GO:0016185; P:synaptic vesicle budding from presynaptic membrane; IMP:FlyBase.
 GO:0048499; P:synaptic vesicle membrane organization; IMP:FlyBase. 
Interpro
 IPR022812; Dynamin.
 IPR000375; Dynamin_central.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR003130; GED.
 IPR020850; GTPase_effector_domain_GED.
 IPR027417; P-loop_NTPase.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF01031; Dynamin_M
 PF00350; Dynamin_N
 PF02212; GED
 PF00169; PH 
SMART
 SM00053; DYNc
 SM00302; GED
 SM00233; PH 
PROSITE
 PS00410; DYNAMIN
 PS51388; GED
 PS50003; PH_DOMAIN 
PRINTS
 PR00195; DYNAMIN.