UniProt Accession

 MYPR_MOUSE; P60202; P04400; P06905; Q9WUS9 

Genbank Protein ID

 M15442; M15442; M15442; X07215; X07216; X07217; X07218; X07219; X07220; X07221; M37335; M37329; M37330; M37331; M37332; M37333; M37334; M14674; M16472; BC027010; X06375 

Genbank Nucleotide ID

 AAA39951.1; AAA39952.1; AAA39953.1; CAA30184.1; CAA30184.1; CAA30184.1; CAA30184.1; CAA30184.1; CAA30184.1; CAA30184.1; AAA39954.1; AAA39954.1; AAA39954.1; AAA39954.1; AAA39954.1; AAA39954.1; AAA39954.1; AAA39955.1; AAA39950.1; AAH27010.1; CAB40821.1 

Protein Name

 Myelin proteolipid protein 

Protein Synonyms/Alias

 PLP; Lipophilin 

Gene Name

 Plp1 

Gene Synonyms/Alias

 Plp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
105	RQIFGDYKTTICGKG	ubiquitination	[1]
111	YKTTICGKGLSATVT	ubiquitination	[1]
122	ATVTGGQKGRGSRGQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. 

Sequence Annotation

 LIPID 6 6 S-palmitoyl cysteine (By similarity).
 LIPID 7 7 S-palmitoyl cysteine (By similarity).
 LIPID 10 10 S-palmitoyl cysteine (By similarity).
 LIPID 109 109 S-palmitoyl cysteine (By similarity).
 LIPID 139 139 S-palmitoyl cysteine (By similarity).
 LIPID 141 141 S-palmitoyl cysteine (By similarity).
 LIPID 199 199 O-palmitoyl serine (By similarity).
 DISULFID 184 228 By similarity.
 DISULFID 201 220 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Lipoprotein; Membrane; Palmitate; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043209; C:myelin sheath; IDA:MGI.
 GO:0019911; F:structural constituent of myelin sheath; IEA:Compara.
 GO:0048469; P:cell maturation; IMP:MGI.
 GO:0022010; P:central nervous system myelination; IMP:MGI.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:Compara.
 GO:0042759; P:long-chain fatty acid biosynthetic process; IMP:MGI.
 GO:0010628; P:positive regulation of gene expression; IMP:MGI. 

Interpro

 IPR001614; Myelin_PLP.
 IPR018237; Myelin_PLP_CS. 

Pfam

 PF01275; Myelin_PLP 

SMART

 SM00002; PLP 

PROSITE

 PS00575; MYELIN_PLP_1
 PS01004; MYELIN_PLP_2 

PRINTS

 PR00214; MYELINPLP.