UniProt Accession

 TNNI3_RAT; P23693; Q4PP23 

Genbank Protein ID

 M57679; X58499; M92074; U77354; DQ062462 

Genbank Nucleotide ID

 AAA63504.1; CAA41402.1; AAA42294.1; AAB52234.1; AAY63993.1 

Protein Name

 Troponin I, cardiac muscle 

Protein Synonyms/Alias

 Cardiac troponin I 

Gene Name

 Tnni3 

Gene Synonyms/Alias

 Ctni; Tni 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
51	ASRKLQLKTLMLQIA	acetylation	[1]
59	TLMLQIAKQEMEREA	acetylation	[1]
107	QLHARVDKVDEERYD	acetylation	[1]
121	DVEAKVTKNITEIAD	acetylation	[1]
132	EIADLTQKIYDLRGK	acetylation	[1]
141	YDLRGKFKRPTLRRV	acetylation	[1]
165	ALLGTRAKESLDLRA	acetylation	[1]
178	RAHLKQVKKEDIEKE	acetylation	[1]
184	VKKEDIEKENREVGD	acetylation	[1]
194	REVGDWRKNIDALSG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. 

Sequence Annotation

 REGION 33 80 Involved in binding TNC.
 REGION 130 151 Involved in binding TNC and actin.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 5 5 Phosphoserine (By similarity).
 MOD_RES 6 6 Phosphoserine (By similarity).
 MOD_RES 23 23 Phosphoserine; by PKA and PKD/PRKD1 (By
 MOD_RES 24 24 Phosphoserine; by PKA and PKD/PRKD1 (By
 MOD_RES 27 27 Phosphotyrosine (By similarity).
 MOD_RES 32 32 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 43 43 Phosphoserine; by PKC/PRKCE (By
 MOD_RES 45 45 Phosphoserine; by PKC/PRKCE (By
 MOD_RES 52 52 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 78 78 Phosphoserine (By similarity).
 MOD_RES 79 79 Phosphothreonine (By similarity).
 MOD_RES 130 130 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 144 144 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 151 151 Phosphoserine; by PAK3 (By similarity).
 MOD_RES 167 167 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphoserine (By similarity).  

Keyword

 Acetylation; Actin-binding; Calcium; Complete proteome; Metal-binding; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0005861; C:troponin complex; TAS:RGD.
 GO:0019855; F:calcium channel inhibitor activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0060048; P:cardiac muscle contraction; IDA:RGD.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0032780; P:negative regulation of ATPase activity; IEA:Compara.
 GO:0006940; P:regulation of smooth muscle contraction; IMP:RGD.
 GO:0001980; P:regulation of systemic arterial blood pressure by ischemic conditions; IEA:Compara.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 

Interpro

 IPR001978; Troponin.
 IPR021666; Troponin-I_N. 

Pfam

 PF00992; Troponin
 PF11636; Troponin-I_N 

SMART

  

PROSITE

  

PRINTS