| Tag | Content |
|---|
| CPLM ID | CPLM-024180 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 22 member 4 |
Protein Synonyms/Alias | Organic cation/carnitine transporter 1 |
Gene Name | Slc22a4 |
Gene Synonyms/Alias | Octn1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 299 | EAEQIIQKAAKMNSI | ubiquitination | [1] | | 302 | QIIQKAAKMNSIVAP | ubiquitination | [1] | | 547 | VDREESPKVLITAF* | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. |
Sequence Annotation | NP_BIND 218 225 ATP (Potential).
CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
CARBOHYD 91 91 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; Complete proteome; Glycoprotein; Ion transport; Membrane; Nucleotide-binding; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC LVPDTVNLSS 60
SWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSAMGLEPG QDVDLEQLEQ ESCLDGWEYD 120
KDIFLSTIVT EWNLVCEDDW KTPLTTSLFF VGVLCGSFVS GQLSDRFGRK KVLFATMAVQ 180
TGFSFVQIFS TNWEMFTVLF AIVGMGQISN YVVAFILGTE ILSKSVRIIF STLGVCTFFA 240
IGYMVLPLFA YFIRDWRMLL LALTLPGLFC VPLWWFIPES PRWLISQRRF AEAEQIIQKA 300
AKMNSIVAPA GIFDPLELQE LNSLKQQKVI ILDLFRTRNI ATITVMAVML WMLTSVGYFA 360
LSLNVPNLHG DVYLNCFLSG LIEVPAYFTA WLLLRTLPRR YIIAGVLFWG GGVLLLIQVV 420
PEDYNFVSIG LVMLGKFGIT SAFSMLYVFT AELYPTLVRN MAVGITSMAS RVGSIIAPYF 480
VYLGAYNRLL PYILMGSLTV LIGIITLFFP ESFGVTLPEN LEQMQKVRGF RCGKKSTVSV 540
DREESPKVLI TAF 553 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005739; C:mitochondrion; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0015226; F:carnitine transmembrane transporter activity; IDA:MGI. GO:0015491; F:cation:cation antiporter activity; IEA:Compara. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0009437; P:carnitine metabolic process; IGI:MGI. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. GO:0006641; P:triglyceride metabolic process; IGI:MGI. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |