UniProt Accession

 3HAO_YEAST; P47096; D6VWJ8 

Genbank Protein ID

 Z49525; X87297; AY558309; BK006943 

Genbank Nucleotide ID

 CAA89550.1; CAA60720.1; AAS56635.1; DAA08814.1 

Protein Name

 3-hydroxyanthranilate 3,4-dioxygenase 

Protein Synonyms/Alias

 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD; Biosynthesis of nicotinic acid protein 1 

Gene Name

 BNA1 

Gene Synonyms/Alias

 HAD1; YJR025C; J1550 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
60	TPEWFYQKKGSMLLK	ubiquitination	[1]
67	KKGSMLLKVVDETDA	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. 

Sequence Annotation

 METAL 49 49 Iron; catalytic.
 METAL 55 55 Iron; catalytic.
 METAL 97 97 Iron; catalytic.
 METAL 126 126 Divalent metal cation.
 METAL 129 129 Divalent metal cation.
 METAL 163 163 Divalent metal cation.
 METAL 166 166 Divalent metal cation.
 BINDING 45 45 Dioxygen (By similarity).
 BINDING 55 55 Substrate (By similarity).
 BINDING 101 101 Substrate (By similarity).
 BINDING 111 111 Substrate (By similarity).
 MOD_RES 176 176 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Phosphoprotein; Pyridine nucleotide biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IMP:SGD.
 GO:0008198; F:ferrous iron binding; IEA:HAMAP.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IGI:SGD.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0006569; P:tryptophan catabolic process; IEA:HAMAP. 

Interpro

 IPR010329; 3hydroanth_dOase.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 

Pfam

 PF06052; 3-HAO 

SMART

  

PROSITE

  

PRINTS