UniProt Accession

 1433Z_DROME; P29310; A4UZB2; A4UZB3; C1C593; C9QP27; O01665; Q0E9D5; Q0E9D6; Q0E9D7; Q8IGB9; Q8MKV5; Q9V5G6 

Genbank Protein ID

 M77518; Y12573; Y12573; AE013599; AE013599; AE013599; AE013599; AE013599; AE013599; AE013599; AE013599; BT001855; BT082022; BT088441; BT099909 

Genbank Nucleotide ID

 AAA28324.1; CAA73152.1; CAA73153.1; AAF58842.4; AAF58843.3; AAM71060.1; AAM71063.2; AAM71064.2; AAS64884.1; AAX52715.1; AAX52716.1; AAN71617.1; ACO72859.1; ACR44245.1; ACX32980.1 

Protein Name

 14-3-3 protein zeta 

Protein Synonyms/Alias

 14-3-3-like protein; Protein Leonardo 

Gene Name

 14-3-3zeta 

Gene Synonyms/Alias

 14-3-3; 14-3-3EZ; leo; THAP; CG17870 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
52	NLLSVAYKNVVGARR	acetylation	[1]
71	VISSIEQKTEASARK	acetylation	[1]
111	LDKYLIPKASNPESK	acetylation	[1]
118	KASNPESKVFYLKMK	acetylation	[1]
123	ESKVFYLKMKGDYYR	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator by decreasing its voltage sensitivity. Inhibits yki activity by restricting its nuclear localization. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045172; C:germline ring canal; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; NAS:FlyBase.
 GO:0042803; F:protein homodimerization activity; IDA:FlyBase.
 GO:0008426; F:protein kinase C inhibitor activity; NAS:FlyBase.
 GO:0007059; P:chromosome segregation; IMP:FlyBase.
 GO:0007294; P:germarium-derived oocyte fate determination; IGI:FlyBase.
 GO:0045448; P:mitotic cell cycle, embryonic; IMP:FlyBase.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0008355; P:olfactory learning; NAS:FlyBase.
 GO:0008103; P:oocyte microtubule cytoskeleton polarization; IGI:FlyBase.
 GO:0006457; P:protein folding; IDA:FlyBase.
 GO:0050821; P:protein stabilization; IDA:FlyBase. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.