CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041265
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DBIRD complex subunit KIAA1967 
Protein Synonyms/Alias
 KIAA1967, isoform CRA_b 
Gene Name
 KIAA1967 
Gene Synonyms/Alias
 hCG_2043023 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
342EEEFAGAKLEDSEVRubiquitination[1]
417RLSAEQAKQLVSRVVubiquitination[1, 2, 3, 4]
475GAAPTEHKALVSHNGubiquitination[3]
507GRLYLENKIHTLELKubiquitination[2, 3, 4]
514KIHTLELKLEESHNRubiquitination[2]
530SATEVTNKTLAAEMQubiquitination[1, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 598 AA 
Protein Sequence
MLFVDDMAEP RETPEHPLKQ IKFLLGRKEE EAVLVGGEWS PSLDGLDPQA DPQVLVRTAI 60
RCAQAQTGID LSGCTKWWRF AEFQYLQPGP PRRLQTVVVY LPDVWTIMPT LEEWEALCQQ 120
KAAEAAPPTQ EAQGETEPTE QAPDALEQAA DTSRRNAETP EATTQQETDT DLPEAPPPPL 180
EPAVIARPGC VNLSLHGIVE DRRPKERISF EVMVLAELFL EMLQRDFGYR VYKMLLSLPE 240
KVVSPPEPEK EEAAKEEATK EEEAIKEEVV KEPKDEAQNE GPATESEAPL KEDGLLPKPL 300
SSGGEEEEKP RGEASEDLCE MALDPELLLL RDDGEEEFAG AKLEDSEVRS VASNQSEMEF 360
SSLQDMPKEL DPSAVLPLDC LLAFVFFDAN WCGYLHRRDL ERILLTLGIR LSAEQAKQLV 420
SRVVTQNICQ YRSLQYSRQE GLDGGLPEEV LFGNLDLLPP PGKSTKPGAA PTEHKALVSH 480
NGSLINVGSL LQRAEQQDSG RLYLENKIHT LELKLEESHN RFSATEVTNK TLAAEMQELR 540
VRLAEAEETA RTAERQKSQL QRLLQELRRR LTPLQLEIQR VVEKVRWGWT RRQHSSFP 598 
Gene Ontology
 GO:0006915; P:apoptotic process; IEA:InterPro. 
Interpro
 IPR025224; DBC1/CARP1.
 IPR025954; DBC1/CARP1_inactive_NUDIX_dom. 
Pfam
 PF14443; DBC1 
SMART
  
PROSITE
  
PRINTS