CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034952
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Malic enzyme 
Protein Synonyms/Alias
  
Gene Name
 Me2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
26VHLKEKGKPLMLNPRacetylation[1]
74RFHRNLKKMTSPLEKacetylation[1]
94GIQERNEKLFYRILQacetylation[1]
156NWPENHVKAVVVTDGacetylation[1]
224FYMGLYQKRDRSQLYacetylation[1]
346RKIWMFDKNGLLVKGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 112 112 Proton donor (By similarity).
 ACT_SITE 183 183 Proton acceptor (By similarity).
 METAL 255 255 Divalent metal cation (By similarity).
 METAL 256 256 Divalent metal cation (By similarity).
 METAL 279 279 Divalent metal cation (By similarity).  
Keyword
 Complete proteome; Metal-binding; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 584 AA 
Protein Sequence
MFSRLRAVTT PCTLTCRRVH LKEKGKPLML NPRTNKGMAF TLQERQMLGL QGLLPPKIET 60
QDIQALRFHR NLKKMTSPLE KYIYIMGIQE RNEKLFYRIL QDDIESLMPI VYTPTVGLAC 120
CQYGHIFRRP KGLFISISDR GHVRSIVDNW PENHVKAVVV TDGERILGLG DLGVYGMGIP 180
VGKLCLYTAC AGIQPEKCLP VCIDVGTDNM ALLKDPFYMG LYQKRDRSQL YDDLMDEFMK 240
AITDRYGRNT LIQFEDFGNH NAFRFLKKYQ EKYCTFNDDI QGTAAVALSG LLAAQRVINK 300
PISEHRILFL GAGEAALGIA KLIVISMMES GLSEEEAQRK IWMFDKNGLL VKGRTARIDS 360
NQEPYAHAAS ENIPATFEDA VNKLKPSVII GVAGAGPLFT PGVIKAMAAI NERPIIFALS 420
NPTAQAECTA EDAYTLTEGR CLFASGSPFE PVRLQDGRVF TPGQGNNAYI FPGVALAVIL 480
CEARHISDTV FLEAAKALTS QLTDEELAQG RLYPSLANIQ EVSANIAIKI AEYLYANKMA 540
FRYPEPEDKA KYVKERIWRS NYVSLLPDVY DWPESSLKPP QIPE 584 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016619; F:malate dehydrogenase (oxaloacetate-decarboxylating) activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro. 
Interpro
 IPR015884; Malic_enzyme_CS.
 IPR012301; Malic_N.
 IPR012302; Malic_NAD-bd.
 IPR001891; Malic_OxRdtase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00390; malic
 PF03949; Malic_M 
SMART
 SM00919; Malic_M 
PROSITE
 PS00331; MALIC_ENZYMES 
PRINTS
 PR00072; MALOXRDTASE.