CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026224
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha II polypeptide, isoform CRA_f 
Protein Synonyms/Alias
 Prolyl 4-hydroxylase subunit alpha-2 
Gene Name
 P4ha2 
Gene Synonyms/Alias
 mCG_13782 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
482GAAIWPKKGTAVFWYacetylation[1]
482GAAIWPKKGTAVFWYsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Collagen; Complete proteome; Dioxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 537 AA 
Protein Sequence
MKLQVLVLVL LMSWFGVLSW VQAEFFTSIG HMTDLIYAEK DLVQSLKEYI LVEEAKLAKI 60
KSWASKMEAL TSRSAADPEG YLAHPVNAYK LVKRLNTDWP ALGDLVLQDA SAGFVANLSV 120
QRQFFPTDED ESGAARALMR LQDTYKLDPD TISRGELPGT KYQAMLSVDD CFGLGRSAYN 180
EGDYYHTVLW MEQVLKQLDA GEEATVTKSL VLDYLSYAVF QLGDLHRAVE LTRRLLSLDP 240
SHERAGGNLR YFERLLEEER GKSLSNQTDA GLATQENLYE RPTDYLPERD VYESLCRGEG 300
VKLTPRRQKK LFCRYHHGNR VPQLLIAPFK EEDEWDSPHI VRYYDVMSDE EIERIKEIAK 360
PKLARATVRD PKTGVLTVAS YRVSKSSWLE EDDDPVVARV NRRMQHITGL TVKTAELLQV 420
ANYGMGGQYE PHFDFSRSDE QDAFKRLGTG NRVATFLNYM SDVEAGGATV FPDLGAAIWP 480
KKGTAVFWYN LLRSGEGDYR TRHAACPVLV GCKWVSNKWF HERGQEFLRP CGTTEVD 537 
Gene Ontology
 GO:0005581; C:collagen; IEA:UniProtKB-KW.
 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0004656; F:procollagen-proline 4-dioxygenase activity; IDA:MGI.
 GO:0018401; P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline; IDA:MGI. 
Interpro
 IPR005123; Oxoglu/Fe-dep_dioxygenase.
 IPR006620; Pro_4_hyd_alph.
 IPR013547; Pro_4_hyd_alph_N.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF03171; 2OG-FeII_Oxy
 PF08336; P4Ha_N 
SMART
 SM00702; P4Hc 
PROSITE
 PS51471; FE2OG_OXY
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS