CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023594
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipoyltransferase 1, mitochondrial 
Protein Synonyms/Alias
 Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligase 
Gene Name
 LIPT1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
131YDRMENLKLIVRALNubiquitination[1, 2]
150QLDVQATKRFDLLLDubiquitination[1, 2]
168KISGTASKIGRTTAYubiquitination[1, 2]
213ASIPSLVKNLLEKDPubiquitination[1, 2]
264PGINSKAKELQTWEWubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity). 
Sequence Annotation
 BINDING 107 107 Substrate; via amide nitrogen and
 BINDING 151 151 Substrate (By similarity).
 BINDING 161 161 Substrate (By similarity).
 BINDING 179 179 Substrate (By similarity).  
Keyword
 Acyltransferase; Complete proteome; Mitochondrion; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MLIPFSMKNC FQLLCNCQVP AAGFKKTVKN GLILQSISND VYQNLAVEDW IHDHMNLEGK 60
PILFFWQNSP SVVIGRHQNP WQECNLNLMR EEGIKLARRR SGGGTVYHDM GNINLTFFTT 120
KKKYDRMENL KLIVRALNAV QPQLDVQATK RFDLLLDGQF KISGTASKIG RTTAYHHCTL 180
LCSTDGTFLS SLLKSPYQGI RSNATASIPS LVKNLLEKDP TLTCEVLMNA VATEYAAYHQ 240
IDNHIHLINP TDETLFPGIN SKAKELQTWE WIYGKTPKFS INTSFHVLYE QSHLEIKVFI 300
DIKNGRIEIC NIEAPDHWLP LEIRDKLNSS LIGSKFCPTE TTMLTNILLR TCPQDHKLNS 360
KWNILCEKIK GIM 373 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
 GO:0006464; P:cellular protein modification process; TAS:ProtInc.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0009249; P:protein lipoylation; IEA:InterPro. 
Interpro
 IPR004143; BPL_LipA_LipB.
 IPR004562; LipoylTrfase_LipoateP_Ligase. 
Pfam
 PF03099; BPL_LplA_LipB 
SMART
  
PROSITE
  
PRINTS