UniProt Accession

 GDE1_HUMAN; Q9NZC3; O43334; Q6PKF7; Q7KYR4 

Genbank Protein ID

 AF212862; AY463154; U91321; AC003108; BC014981; BC025273 

Genbank Nucleotide ID

 AAF65234.1; AAR25624.1; AAC05440.1; AAC05803.1; AAH14981.1; AAH25273.1 

Protein Name

 Glycerophosphodiester phosphodiesterase 1 

Protein Synonyms/Alias

 Membrane-interacting protein of RGS16; RGS16-interacting membrane protein 

Gene Name

 GDE1 

Gene Synonyms/Alias

 MIR16 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	CRALQVLKPRDRISA	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity). 

Sequence Annotation

 DOMAIN 70 325 GDPD.
 METAL 97 97 Magnesium (Potential).
 METAL 99 99 Magnesium (Potential).
 METAL 174 174 Magnesium (Potential).
 CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
 CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Cytoplasm; Glycoprotein; Hydrolase; Magnesium; Membrane; Metal-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:UniProtKB.
 GO:0008889; F:glycerophosphodiester phosphodiesterase activity; TAS:UniProtKB.
 GO:0047395; F:glycerophosphoinositol glycerophosphodiesterase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006071; P:glycerol metabolic process; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; TAS:UniProtKB. 

Interpro

 IPR004129; GlyceroP-diester-Pdiesterase.
 IPR017946; PLC-like_Pdiesterase_TIM-brl. 

Pfam

 PF03009; GDPD 

SMART

  

PROSITE

  

PRINTS