| Tag | Content |
|---|
| CPLM ID | CPLM-016875 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 2-hydroxyacyl-CoA lyase 1 |
Protein Synonyms/Alias | 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2 |
Gene Name | Hacl1 |
Gene Synonyms/Alias | 2hpcl; Hpcl2; Phyh2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 351 | WQYPTDSKWWETLRE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. |
Sequence Annotation | REGION 404 489 Thiamine pyrophosphate binding (By
MOTIF 579 581 Microbody targeting signal (By
METAL 458 458 Magnesium (By similarity).
METAL 485 485 Magnesium (By similarity).
BINDING 63 63 Thiamine pyrophosphate (By similarity).
MOD_RES 4 4 Phosphoserine (By similarity).
MOD_RES 10 10 Phosphoserine (By similarity). |
Keyword | Complete proteome; Direct protein sequencing; Lyase; Magnesium; Metal-binding; Peroxisome; Phosphoprotein; Reference proteome; Thiamine pyrophosphate. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 581 AA |
Protein Sequence | MSESNSAEGS DRSEEQVSGA KVIAQALKTQ DVEYMFGVVG IPVTEIALAA QELGIKYIGM 60
RNEQAACYAA SAVGYLTGRP GVCLVVSGPG LIHALGGMAN ANMNCWPLIV IGGSSERNQE 120
AMGAFQEFPQ VEACRLYSKF SARPSSIQHI PFVIEKAVRS SIYGRPGACY IDVPADLVTL 180
QESTTSIKYK ECCMPPPLSL AETSAVRAAA SVLRSAKQPL LIIGKGAAYS HAEDSIRKLV 240
ELCNLPFLPT PMGKGVVPDN HPNCVGAARS RALQFADVIV LFGARLNWIL HFGLPPRYQA 300
DVKFIQIDIC AEELGNNVRP SVTLLGDVNA VSKQLLEQFV KNPWQYPTDS KWWETLREKR 360
KNNEAVSKEL ASKKSLPMNY YTVFYHVQEQ LPRNCFIVSE GANTMDIGRT VLQNYLPRHR 420
LDAGSFGTMG VGLGFAIAAA VVAKERSPGQ RVICVEGDSA FGFSGMEVET ICRYNLPIII 480
LVVNNNGIYQ GFDADTWGKI LNFQGTATTI PPMCLLPNSH YEQVMTAFGG KGYFVQTPEE 540
LQDSLRQALK DTSKPCLINI MIEPQSTRKA QDFHWLTRSN I 581 |
Gene Ontology | GO:0005777; C:peroxisome; IDA:HGNC. GO:0016830; F:carbon-carbon lyase activity; IDA:HGNC. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0030976; F:thiamine pyrophosphate binding; IDA:HGNC. GO:0001561; P:fatty acid alpha-oxidation; IDA:HGNC. GO:0051259; P:protein oligomerization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |