UniProt Accession

 RANB3_MOUSE; Q9CT10; A6H6I9; Q3TIS4; Q3U2G4; Q3UYG7 

Genbank Protein ID

 AK011541; AK133949; AK134696; AK155301; AK167731; BC145892; BC145894 

Genbank Nucleotide ID

 BAB27684.1; BAE21946.1; BAE22245.1; BAE33176.1; BAE39772.1; AAI45893.1; AAI45895.1 

Protein Name

 Ran-binding protein 3 

Protein Synonyms/Alias

 RanBP3 

Gene Name

 Ranbp3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	ADLANEEKPAVAPSV	acetylation	[1]
21	PSVFVFQKDKGQKRS	acetylation	[1, 2]
290	SQEAAPKKESLAESA	ubiquitination	[3]
337	CKLFVFDKTSQSWVE	acetylation	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). 

Sequence Annotation

 DOMAIN 302 442 RanBD1.
 MOD_RES 21 21 N6-acetyllysine (By similarity).
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 33 33 Phosphoserine.
 MOD_RES 40 40 Phosphoserine.
 MOD_RES 47 47 Phosphotyrosine.
 MOD_RES 56 56 Phosphothreonine (By similarity).
 MOD_RES 146 146 Phosphoserine.
 MOD_RES 148 148 Phosphoserine.
 MOD_RES 257 257 Phosphoserine (By similarity).
 MOD_RES 277 277 Phosphoserine (By similarity).
 MOD_RES 279 279 Phosphoserine (By similarity).
 MOD_RES 463 463 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046907; P:intracellular transport; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR011993; PH_like_dom.
 IPR000156; Ran_bind_dom. 

Pfam

 PF00638; Ran_BP1 

SMART

 SM00160; RanBD 

PROSITE

 PS50196; RANBD1 

PRINTS