CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016833
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Structural maintenance of chromosomes protein 5 
Protein Synonyms/Alias
 SMC protein 5; SMC-5; mSMC5; Protein expressed in male leptotene and zygotene spermatocytes 453; MLZ-453 
Gene Name
 Smc5 
Gene Synonyms/Alias
 Kiaa0594; Smc5l1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
452FDNLMNQKEDKLRQRubiquitination[1]
558SRSLNDLKQYGFFSYubiquitination[1]
629KTSVYSNKVISSNTSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity). 
Sequence Annotation
 NP_BIND 80 87 ATP (Potential).
 REGION 441 644 Flexible hinge.
 MOD_RES 35 35 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; DNA damage; DNA recombination; DNA repair; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Telomere; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1101 AA 
Protein Sequence
MATPSGKAAP PNPQVSKRSL PRDASSEVPS KRKNSNPLPT LPRPSGTFVE GSIVRIAMEN 60
FLTYDICEVS PGPHLNMIIG ANGTGKSSIV CAICLGLAGK PAFMGRADKV GFFVKRGCSK 120
GLVEIELFRT SGNLIITREI DVIKNQSFWF INKKPVTQKI VEEQVAALNI QVGNLCQFLP 180
QDKVGEFAKL SKIELLEATE KSVGPPEMHR YHCELKNFRE KEKQLETSCK EKTEYLEKMV 240
QRNERYKQDV ERFYERKRHL DLIEMLEAKR PWVEYENVRQ EYEGVKLIRD RVKEEVRKLK 300
EGQIPMTRRI EEIDRQRHTL EVRIKEKSTD IKEASQKCKQ RQDLIERKDR QIKELQQALT 360
VKQNEELDRQ KRISNTRKMI EDLQSELKTA ENCENLQPQI DTVTNDLRRV QEEKALCEGE 420
IIDKQREKEM LEKQRRSVSD HITRFDNLMN QKEDKLRQRY RDTYDAVLWL RNNRDRFKQR 480
VCEPIMLTIN MKDNKNAKYV ENHISSNDLR AFVFESQEDM EIFLREVRDN KKLRVNAVIA 540
PKISYADKAP SRSLNDLKQY GFFSYLRELF DAPDPVMSYL CCQYHIHEVP VGTERTRERI 600
ERVIQETRLK QIYTAEEKYV LKTSVYSNKV ISSNTSLKVA QFLTVTVDLE QRRHLEEQLK 660
EMNRQLEAVD SGLAALRDTN RHLELKDNEL RLKKKELLER KTRKRQLEQK ISSKLASIRL 720
MEQDTCNLEE EERKASTKIK EINVQKAKLV TELTGLVKIC TSFQIQKVDL ILQNTTVISE 780
KNKLEADYMA SSSQLRVTEQ QFIELDDNRQ RLLQKCKELM KKARQVCNLS ADQAVPQEFQ 840
TQVPTIPNGH SSSPPMAFQD LPNTLDEIDA LLTEERSRAS CFTGLNPSVV EEYSKREVEI 900
QQLTEELQGK KVELDEYREN ISQVKERWLN PLKELVEKIN EKFSNFFSSM QCAGEVDLHT 960
ENEEDYDKYG IRIRVKFRSS TQLHELTPHH QSGGERSVST MLYLMALQEL NRCPFRVVDE 1020
INQGMDPINE RRVFEMVVNT ACKENTSQYF FITPKLLQNL PYSEKMTVLF VYNGPHMLEP 1080
NRWNLKAFQR RRRRITFTQP Q 1101 
Gene Ontology
 GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
 GO:0016605; C:PML body; ISS:UniProtKB.
 GO:0030915; C:Smc5-Smc6 complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0090398; P:cellular senescence; ISS:UniProtKB.
 GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0034184; P:positive regulation of maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
 GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; ISS:UniProtKB.
 GO:0000722; P:telomere maintenance via recombination; ISS:UniProtKB. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC.
 IPR027131; SMC5. 
Pfam
 PF02463; SMC_N 
SMART
  
PROSITE
  
PRINTS