| Tag | Content |
|---|
| CPLM ID | CPLM-003794 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipid-A-disaccharide synthase |
Protein Synonyms/Alias | |
Gene Name | lpxB |
Gene Synonyms/Alias | pgsB; b0182; JW0177 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 156 | FEKAFYDKYNVPCRF | acetylation | [1] | | 214 | MLSADFLKTAQLLRQ | acetylation | [1] | | 236 | VVPLVNAKRREQFER | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
Sequence Annotation | |
Keyword | Complete proteome; Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 382 AA |
Protein Sequence | MTEQRPLTIA LVAGETSGDI LGAGLIRALK EHVPNARFVG VAGPRMQAEG CEAWYEMEEL 60
AVMGIVEVLG RLRRLLHIRA DLTKRFGELK PDVFVGIDAP DFNITLEGNL KKQGIKTIHY 120
VSPSVWAWRQ KRVFKIGRAT DLVLAFLPFE KAFYDKYNVP CRFIGHTMAD AMPLDPDKNA 180
ARDVLGIPHD AHCLALLPGS RGAEVEMLSA DFLKTAQLLR QTYPDLEIVV PLVNAKRREQ 240
FERIKAEVAP DLSVHLLDGM GREAMVASDA ALLASGTAAL ECMLAKCPMV VGYRMKPFTF 300
WLAKRLVKTD YVSLPNLLAG RELVKELLQE ECEPQKLAAA LLPLLANGKT SHAMHDTFRE 360
LHQQIRCNAD EQAAQAVLEL AQ 382 |
Gene Ontology | GO:0019897; C:extrinsic to plasma membrane; IDA:EcoliWiki. GO:0008915; F:lipid-A-disaccharide synthase activity; IDA:EcoliWiki. GO:0005543; F:phospholipid binding; IDA:EcoliWiki. GO:0009245; P:lipid A biosynthetic process; IMP:EcoliWiki. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |