UniProt Accession

 CUSR_ECOLI; P0ACZ8; P77380 

Genbank Protein ID

 AF245661; U82598; U00096; AP009048; U82579 

Genbank Nucleotide ID

 AAF70175.1; AAB40769.1; AAC73672.1; BAA35205.1; AAB41754.1 

Protein Name

 Transcriptional regulatory protein CusR 

Protein Synonyms/Alias

  

Gene Name

 cusR 

Gene Synonyms/Alias

 ylcA; b0571; JW0560 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
10	LLIVEDEKKTGEYLT	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. 

Sequence Annotation

 DOMAIN 1 116 Response regulatory.
 MOD_RES 51 51 4-aspartylphosphate (By similarity).  

Keyword

 Activator; Complete proteome; Copper; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0032993; C:protein-DNA complex; IDA:EcoCyc.
 GO:0001114; C:protein-DNA-RNA complex; IDA:EcoCyc.
 GO:0001046; F:core promoter sequence-specific DNA binding; IDA:EcoCyc.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0000160; P:phosphorelay signal transduction system; IDA:EcoCyc.
 GO:0010628; P:positive regulation of gene expression; IMP:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0046688; P:response to copper ion; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR006291; Sig_transdc_resp-reg_metal.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00072; Response_reg
 PF00486; Trans_reg_C 

SMART

 SM00448; REC
 SM00862; Trans_reg_C 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS