CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041638
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 
Protein Synonyms/Alias
  
Gene Name
 Enpp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
237MRPVYPTKTFPNHYSacetylation[1]
260SHGIIDNKMYDPKMNacetylation[1]
277FSLKSKEKFNPLWYKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 905 AA 
Protein Sequence
MERDGEQAGQ GPRHGPAGNG RELESPAAAS LLAPMDLGEE PLEKAERART AKDPNTYKVL 60
SLVLSVCVLT TILGCIFGLK PSCAKEVKSC KGRCFERTFS NCRCDAACVS LGNCCLDFQE 120
TCVEPTHIWT CNKFRCGEKR LSRFVCSCAD DCKAHNDCCI NYSSVCQEKK SWVEEACETI 180
DAPQCPAEFE SPPTLLFSLD GFRAEYLHTW GGLLPVISKL KNCGTYTKNM RPVYPTKTFP 240
NHYSIVTGLY PESHGIIDNK MYDPKMNASF SLKSKEKFNP LWYKGQPIWV TANHQEVRSG 300
TYFWPGSDVE IDGILPDIYK VYNGSVPFEE RILAVLEWLQ LPSYERPHFY TLYLEEPDSS 360
GHSHGPVSSE VIKALQKVDH IVGMLMDGLK DLGLDKCLNL ILISDHGMEQ GSCKKYVYLN 420
KYLGDVNNVK VVYGPAARLR PTEVPETYYS FNYEALAKNL SCRETNQHFR PYLKHFLPKR 480
LHFAKNDRIE PLTFYLDPQW QLALNPSERK YCGSGFHGSD NLFSNMQALF IGYGPAFKHG 540
AEVDSFENIE VYNLMCDLLG LIPAPNNGSH GSLNHLLKKP IYTPSHPKEE SFLSQCPIKS 600
VSSDLGCTCD PSIVPIMDFE KQFNLTTDAE DVYSMTVPNG RPRNLQKQHR VCLLHQQQFL 660
TGYSLDLLMP LWTSYTFLSN DQFSTDDFSN CLYQDLRIPL SPMHKCSYYK STSKLSYGFL 720
TPPRLNRVSR QIYSEALLTS NIVPMYQSFQ VIWQYLHDTV LRRYAQERNG VNVVSGPVFD 780
FDYDGRYDSS EILKQNTRVI RSQENLIPTH FFIVLTSCKQ LSESPLKCTA LESSAFLLPH 840
RPDNIESCTH GKQESAWVEE LLALHRARVT DVELITGLSF YQDRQESVSE LLRLKTHLPI 900
FSQED 905 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IEA:Compara.
 GO:0004551; F:nucleotide diphosphatase activity; IEA:Compara.
 GO:0030247; F:polysaccharide binding; IEA:InterPro.
 GO:0005044; F:scavenger receptor activity; IEA:InterPro.
 GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; IEA:Compara.
 GO:0046849; P:bone remodeling; IEA:Compara.
 GO:0030643; P:cellular phosphate ion homeostasis; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0006091; P:generation of precursor metabolites and energy; IEA:Compara.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0030505; P:inorganic diphosphate transport; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0045599; P:negative regulation of fat cell differentiation; IEA:Compara.
 GO:0046325; P:negative regulation of glucose import; IEA:Compara.
 GO:0045719; P:negative regulation of glycogen biosynthetic process; IEA:Compara.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Compara.
 GO:0030279; P:negative regulation of ossification; IEA:Compara.
 GO:0031953; P:negative regulation of protein autophosphorylation; IEA:Compara.
 GO:0009143; P:nucleoside triphosphate catabolic process; IEA:Compara.
 GO:0030730; P:sequestering of triglyceride; IEA:Compara. 
Interpro
 IPR017849; Alkaline_Pase-like_a/b/a.
 IPR017850; Alkaline_phosphatase_core.
 IPR001604; DNA/RNA_non-sp_Endonuclease.
 IPR024873; E-NPP.
 IPR020821; Extracellular_endonuc_su_A.
 IPR002591; Phosphodiest/P_Trfase.
 IPR020436; Somatomedin_B_chordata.
 IPR001212; Somatomedin_B_dom. 
Pfam
 PF01223; Endonuclease_NS
 PF01663; Phosphodiest
 PF01033; Somatomedin_B 
SMART
 SM00892; Endonuclease_NS
 SM00477; NUC
 SM00201; SO 
PROSITE
 PS00524; SMB_1
 PS50958; SMB_2 
PRINTS
 PR00022; SOMATOMEDINB.