| Tag | Content |
|---|
| CPLM ID | CPLM-022575 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kelch-like protein 13 |
Protein Synonyms/Alias | BTB and kelch domain-containing protein 2 |
Gene Name | KLHL13 |
Gene Synonyms/Alias | BKLHD2; KIAA1309 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 20 | SSHLQSSKAGPTRIF | ubiquitination | [1] | | 94 | EQDLMCIKLHGVSKV | ubiquitination | [1] | | 171 | YNLTEVDKYVNSFVL | ubiquitination | [1] | | 179 | YVNSFVLKNFPALLS | ubiquitination | [1] | | 192 | LSTGEFLKLPFERLA | ubiquitination | [1] | | 235 | PRMDFAAKLMKNIRF | ubiquitination | [1] | | 315 | RQQLVVSKELRMYDE | ubiquitination | [1] | | 363 | SNYDTKGKTAVDTVF | ubiquitination | [1] | | 388 | QVASLNEKRTFFHLS | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. |
Sequence Annotation | DOMAIN 92 161 BTB.
DOMAIN 196 297 BACK.
REPEAT 341 389 Kelch 1.
REPEAT 390 441 Kelch 2.
REPEAT 442 488 Kelch 3.
REPEAT 490 535 Kelch 4.
REPEAT 537 587 Kelch 5.
REPEAT 588 636 Kelch 6. |
Keyword | Alternative splicing; Cell cycle; Cell division; Complete proteome; Kelch repeat; Mitosis; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 655 AA |
Protein Sequence | MKLSLGGSEM GLSSHLQSSK AGPTRIFTSN THSSVVLQGF DQLRLEGLLC DVTLMPGDTD 60
DAFPVHRVMM ASASDYFKAM FTGGMKEQDL MCIKLHGVSK VGLRKIIDFI YTAKLSLNMD 120
NLQDTLEAAS FLQILPVLDF CKVFLISGVT LDNCVEVGRI ANTYNLTEVD KYVNSFVLKN 180
FPALLSTGEF LKLPFERLAF VLSSNSLKHC TELELFKATC RWLRLEEPRM DFAAKLMKNI 240
RFPLMTPQEL INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDTTHL 300
VTLGGVLRQQ LVVSKELRMY DEKAHEWKSL APMDAPRYQH GIAVIGNFLY VVGGQSNYDT 360
KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGY LYAVGGRNAA GELPTVECYN 420
PRTNEWTYVA KMSEPHYGHA GTVYGGVMYI SGGITHDTFQ KELMCFDPDT DKWIQKAPMT 480
TVRGLHCMCT VGERLYVIGG NHFRGTSDYD DVLSCEYYSP ILDQWTPIAA MLRGQSDVGV 540
AVFENKIYVV GGYSWNNRCM VEIVQKYDPD KDEWHKVFDL PESLGGIRAC TLTVFPPEET 600
TPSPSRESPL SAP 613 |
Gene Ontology | GO:0031463; C:Cul3-RING ubiquitin ligase complex; IDA:UniProtKB. GO:0000910; P:cytokinesis; IMP:UniProtKB. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |