CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005748
UniProt Accession
Genbank Protein ID
 M64488 
Genbank Nucleotide ID
Protein Name
 Synaptotagmin-2 
Protein Synonyms/Alias
 Synaptotagmin II; SytII 
Gene Name
 Syt2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
106KEKGKGMKNAMNMKDubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. 
Sequence Annotation
 DOMAIN 156 245 C2 1.
 DOMAIN 287 378 C2 2.
 REGION 136 382 Phospholipid binding (Probable).
 METAL 172 172 Calcium 2; via carbonyl oxygen (By
 METAL 173 173 Calcium 1 (By similarity).
 METAL 173 173 Calcium 2 (By similarity).
 METAL 179 179 Calcium 1 (By similarity).
 METAL 231 231 Calcium 1 (By similarity).
 METAL 231 231 Calcium 2 (By similarity).
 METAL 232 232 Calcium 1; via carbonyl oxygen (By
 METAL 233 233 Calcium 1 (By similarity).
 METAL 233 233 Calcium 2 (By similarity).
 METAL 233 233 Calcium 3 (By similarity).
 METAL 236 236 Calcium 3 (By similarity).
 METAL 237 237 Calcium 3; via carbonyl oxygen (By
 METAL 239 239 Calcium 2 (By similarity).
 METAL 239 239 Calcium 3 (By similarity).
 CARBOHYD 32 32 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Calcium; Cell junction; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MRNIFKRNQE PIVAPATTTA TMPLAPAAPA DNSTESTGTG ESQEDMFAKL KDKFFNEINK 60
IPLPPWALIA MAVVAGLLLL TCCFCICKKC CCKKKKNKKE KGKGMKNAMN MKDMKGGQDD 120
DDAETGLTEG EGEGEEEKEP ENLGKLQFSL DYDFQANQLT VGVLQAAELP ALDMGGTSDP 180
YVKVFLLPDK KKKYETKVHR KTLNPAFNET FTFKVPYQEL GGKTLVMAIY DFDRFSKHDI 240
IGEVKVPMNT VDLGQPIEEW RDLQGGEKEE PEKLGDICTS LRYVPTAGKL TVCILEAKNL 300
KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT VKKKTLNPYF NESFSFEIPF EQIQKVQVVV 360
TVLDYDKLGK NEAIGKIFVG SNATGTELRH WSDMLANPRR PIAQWHSLKP EEEVDALLGK 420
NK 422 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030672; C:synaptic vesicle membrane; TAS:RGD.
 GO:0005509; F:calcium ion binding; TAS:RGD.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:BHF-UCL.
 GO:0019905; F:syntaxin binding; IDA:BHF-UCL.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0016079; P:synaptic vesicle exocytosis; TAS:RGD. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR001565; Synaptotagmin. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS
 PR00360; C2DOMAIN.
 PR00399; SYNAPTOTAGMN.