UniProt Accession

 NAA50_HUMAN; Q9GZZ1; D3DN74; Q68DQ1 

Genbank Protein ID

 AK023090; AK023256; CR749314; CH471052; CH471052; BC012731 

Genbank Nucleotide ID

 BAB14397.1; BAB14490.1; CAH18169.1; EAW79629.1; EAW79630.1; AAH12731.1 

Protein Name

 N-alpha-acetyltransferase 50 

Protein Synonyms/Alias

 N-acetyltransferase 13; N-acetyltransferase 5; hNAT5; N-acetyltransferase san homolog; hSAN; NatE catalytic subunit 

Gene Name

 NAA50 

Gene Synonyms/Alias

 MAK3; NAT13; NAT5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	PHNIKQLKRLNQVIF	ubiquitination	[1]
34	FPVSYNDKFYRKFGF	acetylation	[2, 3, 4]
34	FPVSYNDKFYRKFGF	ubiquitination	[1, 5, 6]
38	YNDKFYRKFGFEIIE	ubiquitination	[1, 6]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity. 

Sequence Annotation

 DOMAIN 6 155 N-acetyltransferase.
 REGION 79 90 Coenzyme A binding.
 MOD_RES 12 12 Phosphothreonine.
 MOD_RES 34 34 N6-acetyllysine.
 MOD_RES 37 37 N6-acetyllysine.
 MOD_RES 110 110 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
 GO:0006474; P:N-terminal protein amino acid acetylation; TAS:HGNC. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS