CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017590
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium bicarbonate transporter-like protein 11 
Protein Synonyms/Alias
 Bicarbonate transporter-related protein 1; Sodium borate cotransporter 1; NaBC1; Solute carrier family 4 member 11 
Gene Name
 SLC4A11 
Gene Synonyms/Alias
 BTR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
284SDIAFRQKLLETRTEubiquitination[1]
295TRTEEEFKEALVHQRubiquitination[1, 2]
344KDFVPFGKGIREDIAubiquitination[1, 2]
635FREIEMSKFRYNPSEubiquitination[2]
752YDTIVNVKETRLTSLubiquitination[1, 2, 3, 4]
810QRVALLLKEQTAYPPubiquitination[1, 2, 3]
880LPRIIEAKYLDVMDAubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. 
Sequence Annotation
 REGION 376 891 Membrane (bicarbonate transporter).
 CARBOHYD 545 545 N-linked (GlcNAc...) (Potential).
 CARBOHYD 553 553 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Anion exchange; Cell membrane; Complete proteome; Corneal dystrophy; Disease mutation; Glycoprotein; Ion transport; Membrane; Polymorphism; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 891 AA 
Protein Sequence
MSQVGGRGDR CTQEVQGLVH GAGDLSASLA ENSPTMSQNG YFEDSSYYKC DTDDTFEARE 60
EILGDEAFDT ANSSIVSGES IRFFVNVNLE MQATNTENEA TSGGCVLLHT SRKYLKLKNF 120
KEEIRAHRDL DGFLAQASIV LNETATSLDN VLRTMLRRFA RDPDNNEPNC NLDLLMAMLF 180
TDAGAPMRGK VHLLSDTIQG VTATVTGVRY QQSWLCIICT MKALQKRHVC ISRLVRPQNW 240
GENSCEVRFV ILVLAPPKMK STKTAMEVAR TFATMFSDIA FRQKLLETRT EEEFKEALVH 300
QRQLLTMVSH GPVAPRTKER STVSLPAHRH PEPPKCKDFV PFGKGIREDI ARRFPLYPLD 360
FTDGIIGKNK AVGKYITTTL FLYFACLLPT IAFGSLNDEN TDGAIDVQKT IAGQSIGGLL 420
YALFSGQPLV ILLTTAPLAL YIQVIRVICD DYDLDFNSFY AWTGLWNSFF LALYAFFNLS 480
LVMSLFKRST EEIIALFISI TFVLDAVKGT VKIFWKYYYG HYLDDYHTKR TSSLVSLSGL 540
GASLNASLHT ALNASFLASP TELPSATHSG QATAVLSLLI MLGTLWLGYT LYQFKKSPYL 600
HPCVREILSD CALPIAVLAF SLISSHGFRE IEMSKFRYNP SESPFAMAQI QSLSLRAVSG 660
AMGLGFLLSM LFFIEQNLVA ALVNAPENRL VKGTAYHWDL LLLAIINTGL SLFGLPWIHA 720
AYPHSPLHVR ALALVEERVE NGHIYDTIVN VKETRLTSLG ASVLVGLSLL LLPVPLQWIP 780
KPVLYGLFLY IALTSLDGNQ LVQRVALLLK EQTAYPPTHY IRRVPQRKIH YFTGLQVLQL 840
LLLCAFGMSS LPYMKMIFPL IMIAMIPIRY ILLPRIIEAK YLDVMDAEHR P 891 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; TAS:HGNC.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015106; F:bicarbonate transmembrane transporter activity; IDA:HGNC.
 GO:0046715; F:borate transmembrane transporter activity; IDA:HGNC.
 GO:0015252; F:hydrogen ion channel activity; IDA:HGNC.
 GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
 GO:0046983; F:protein dimerization activity; IDA:UniProtKB.
 GO:0005272; F:sodium channel activity; IDA:HGNC.
 GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro.
 GO:0030003; P:cellular cation homeostasis; IDA:HGNC.
 GO:0042044; P:fluid transport; ISS:UniProtKB.
 GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro. 
Interpro
 IPR011531; HCO3_transpt_C.
 IPR003020; HCO3_transpt_euk.
 IPR016152; PTrfase/Anion_transptr.
 IPR002178; PTS_EIIA_2. 
Pfam
 PF00955; HCO3_cotransp
 PF00359; PTS_EIIA_2 
SMART
  
PROSITE
  
PRINTS
 PR01231; HCO3TRNSPORT.