CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021670
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plexin-A4 
Protein Synonyms/Alias
  
Gene Name
 PLXNA4 
Gene Synonyms/Alias
 KIAA1550; PLXNA4A; PLXNA4B; UNQ2820/PRO34003 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1350YRQERVEKGLKLFAQacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). 
Sequence Annotation
 DOMAIN 24 507 Sema.
 DOMAIN 509 559 PSI 1.
 DOMAIN 655 702 PSI 2.
 DOMAIN 803 856 PSI 3.
 DOMAIN 858 952 IPT/TIG 1.
 DOMAIN 954 1037 IPT/TIG 2.
 DOMAIN 1040 1139 IPT/TIG 3.
 DOMAIN 1142 1230 IPT/TIG 4.
 MOD_RES 1350 1350 N6-acetyllysine.
 CARBOHYD 655 655 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1007 1007 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1132 1132 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1180 1180 N-linked (GlcNAc...) (Potential).
 DISULFID 95 104 By similarity.
 DISULFID 130 138 By similarity.
 DISULFID 284 405 By similarity.
 DISULFID 300 356 By similarity.
 DISULFID 374 393 By similarity.
 DISULFID 510 527 By similarity.
 DISULFID 516 558 By similarity.
 DISULFID 519 536 By similarity.
 DISULFID 530 542 By similarity.
 DISULFID 593 612 By similarity.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1894 AA 
Protein Sequence
MKAMPWNWTC LLSHLLMVGM GSSTLLTRQP APLSQKQRSF VTFRGEPAEG FNHLVVDERT 60
GHIYLGAVNR IYKLSSDLKV LVTHETGPDE DNPKCYPPRI VQTCNEPLTT TNNVNKMLLI 120
DYKENRLIAC GSLYQGICKL LRLEDLFKLG EPYHKKEHYL SGVNESGSVF GVIVSYSNLD 180
DKLFIATAVD GKPEYFPTIS SRKLTKNSEA DGMFAYVFHD EFVASMIKIP SDTFTIIPDF 240
DIYYVYGFSS GNFVYFLTLQ PEMVSPPGST TKEQVYTSKL VRLCKEDTAF NSYVEVPIGC 300
ERSGVEYRLL QAAYLSKAGA VLGRTLGVHP DDDLLFTVFS KGQKRKMKSL DESALCIFIL 360
KQINDRIKER LQSCYRGEGT LDLAWLKVKD IPCSSALLTI DDNFCGLDMN APLGVSDMVR 420
GIPVFTEDRD RMTSVIAYVY KNHSLAFVGT KSGKLKKIRV DGPRGNALQY ETVQVVDPGP 480
VLRDMAFSKD HEQLYIMSER QLTRVPVESC GQYQSCGECL GSGDPHCGWC VLHNTCTRKE 540
RCERSKEPRR FASEMKQCVR LTVHPNNISV SQYNVLLVLE TYNVPELSAG VNCTFEDLSE 600
MDGLVVGNQI QCYSPAAKEV PRIITENGDH HVVQLQLKSK ETGMTFASTS FVFYNCSVHN 660
SCLSCVESPY RCHWCKYRHV CTHDPKTCSF QEGRVKLPED CPQLLRVDKI LVPVEVIKPI 720
TLKAKNLPQP QSGQRGYECI LNIQGSEQRV PALRFNSSSV QCQNTSYSYE GMEINNLPVE 780
LTVVWNGHFN IDNPAQNKVH LYKCGAMRES CGLCLKADPD FACGWCQGPG QCTLRQHCPA 840
QESQWLELSG AKSKCTNPRI TEIIPVTGPR EGGTKVTIRG ENLGLEFRDI ASHVKVAGVE 900
CSPLVDGYIP AEQIVCEMGE AKPSQHAGFV EICVAVCRPE FMARSSQLYY FMTLTLSDLK 960
PSRGPMSGGT QVTITGTNLN AGSNVVVMFG KQPCLFHRRS PSYIVCNTTS SDEVLEMKVS 1020
VQVDRAKIHQ DLVFQYVEDP TIVRIEPEWS IVSGNTPIAV WGTHLDLIQN PQIRAKHGGK 1080
EHINICEVLN ATEMTCQAPA LALGPDHQSD LTERPEEFGF ILDNVQSLLI LNKTNFTYYP 1140
NPVFEAFGPS GILELKPGTP IILKGKNLIP PVAGGNVKLN YTVLVGEKPC TVTVSDVQLL 1200
CESPNLIGRH KVMARVGGME YSPGMVYIAP DSPLSLPAIV SIAVAGGLLI IFIVAVLIAY 1260
KRKSRESDLT LKRLQMQMDN LESRVALECK EAFAELQTDI HELTSDLDGA GIPFLDYRTY 1320
TMRVLFPGIE DHPVLRDLEV PGYRQERVEK GLKLFAQLIN NKVFLLSFIR TLESQRSFSM 1380
RDRGNVASLI MTVLQSKLEY ATDVLKQLLA DLIDKNLESK NHPKLLLRRT ESVAEKMLTN 1440
WFTFLLYKFL KECAGEPLFS LFCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIDYKTL 1500
VLSCVSPDNA NSPEVPVKIL NCDTITQVKE KILDAIFKNV PCSHRPKAAD MDLEWRQGSG 1560
ARMILQDEDI TTKIENDWKR LNTLAHYQVP DGSVVALVSK QVTAYNAVNN STVSRTSASK 1620
YENMIRYTGS PDSLRSRTPM ITPDLESGVK MWHLVKNHEH GDQKEGDRGS KMVSEIYLTR 1680
LLATKGTLQK FVDDLFETIF STAHRGSALP LAIKYMFDFL DEQADKHGIH DPHVRHTWKS 1740
NCLPLRFWVN MIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY 1800
AKDIPSYKNW VERYYSDIGK MPAISDQDMN AYLAEQSRMH MNEFNTMSAL SEIFSYVGKY 1860
SEEILGPLDH DDQCGKQKLA YKLEQVITLM SLDS 1894 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0002116; C:semaphorin receptor complex; TAS:BHF-UCL.
 GO:0017154; F:semaphorin receptor activity; IEA:Compara.
 GO:0021960; P:anterior commissure morphogenesis; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0021793; P:chemorepulsion of branchiomotor axon; IEA:Compara.
 GO:0021610; P:facial nerve morphogenesis; IEA:Compara.
 GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Compara.
 GO:0021784; P:postganglionic parasympathetic nervous system development; IEA:Compara.
 GO:0048841; P:regulation of axon extension involved in axon guidance; IEA:Compara.
 GO:0050923; P:regulation of negative chemotaxis; IEA:Compara.
 GO:0071526; P:semaphorin-plexin signaling pathway; NAS:BHF-UCL.
 GO:0048485; P:sympathetic nervous system development; IEA:Compara.
 GO:0021636; P:trigeminal nerve morphogenesis; IEA:Compara.
 GO:0021644; P:vagus nerve morphogenesis; IEA:Compara. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR013548; Plexin_cytoplasmic_RasGAP_dom.
 IPR002165; Plexin_repeat.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF08337; Plexin_cytopl
 PF01437; PSI
 PF01403; Sema
 PF01833; TIG 
SMART
 SM00429; IPT
 SM00423; PSI
 SM00630; Sema 
PROSITE
 PS51004; SEMA 
PRINTS