CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006042
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Non-specific lipid-transfer protein 
Protein Synonyms/Alias
 NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-chi; SCPX; Sterol carrier protein 2; SCP-2; Sterol carrier protein X; SCP-X 
Gene Name
 Scp2 
Gene Synonyms/Alias
 Scp-2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
34FKANLVFKEIEKKLEacetylation[1]
38LVFKEIEKKLEEEGEacetylation[1]
39VFKEIEKKLEEEGEQacetylation[1]
49EEGEQFVKKIGGIFAacetylation[1]
58IGGIFAFKVKDGPGGacetylation[1]
60GIFAFKVKDGPGGKEacetylation[1]
66VKDGPGGKEATWVVDacetylation[1]
75ATWVVDVKNGKGSVLacetylation[1]
87SVLPNSDKKADCTITacetylation[1]
118QSAFFQGKLKIAGNMacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. 
Sequence Annotation
 DOMAIN 433 543 SCP2.
 MOTIF 545 547 Microbody targeting signal (Potential).
 MOD_RES 8 8 Phosphoserine.
 MOD_RES 142 142 N6-acetyllysine.
 MOD_RES 173 173 N6-acetyllysine.
 MOD_RES 183 183 N6-acetyllysine (By similarity).
 MOD_RES 282 282 N6-acetyllysine.
 MOD_RES 341 341 N6-acetyllysine.
 MOD_RES 425 425 Phosphoserine.
 MOD_RES 438 438 N6-acetyllysine (By similarity).
 MOD_RES 453 453 N6-acetyllysine.
 MOD_RES 470 470 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Acyltransferase; Alternative initiation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid transport; Lipid-binding; Mitochondrion; Peroxisome; Phosphoprotein; Reference proteome; Transferase; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MGFPEAASSF RTHQVSAAPT SSAGDGFKAN LVFKEIEKKL EEEGEQFVKK IGGIFAFKVK 60
DGPGGKEATW VVDVKNGKGS VLPNSDKKAD CTITMADSDL LALMTGKMNP QSAFFQGKLK 120
IAGNMGLAMK LQNLQLQPGK AKL 143 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005777; C:peroxisome; TAS:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0036042; F:long-chain fatty acyl-CoA binding; IEA:Compara.
 GO:0070538; F:oleic acid binding; IEA:Compara.
 GO:0008526; F:phosphatidylinositol transporter activity; IEA:Compara.
 GO:0033814; F:propanoyl-CoA C-acyltransferase activity; IEA:EC.
 GO:0050632; F:propionyl-CoA C2-trimethyltridecanoyltransferase activity; TAS:MGI.
 GO:0006637; P:acyl-CoA metabolic process; TAS:MGI.
 GO:0032959; P:inositol trisphosphate biosynthetic process; IEA:Compara.
 GO:1901373; P:lipid hydroperoxide transport; IEA:Compara.
 GO:0007031; P:peroxisome organization; IMP:MGI.
 GO:0032385; P:positive regulation of intracellular cholesterol transport; IEA:Compara.
 GO:0045940; P:positive regulation of steroid metabolic process; IEA:Compara.
 GO:0006701; P:progesterone biosynthetic process; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara. 
Interpro
 IPR003033; SCP2_sterol-bd_dom.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020615; Thiolase_acyl_enz_int_AS.
 IPR020617; Thiolase_C.
 IPR020613; Thiolase_CS.
 IPR020616; Thiolase_N. 
Pfam
 PF02036; SCP2
 PF02803; Thiolase_C
 PF00108; Thiolase_N 
SMART
  
PROSITE
 PS00098; THIOLASE_1
 PS00737; THIOLASE_2
 PS00099; THIOLASE_3 
PRINTS