| Tag | Content |
|---|
| CPLM ID | CPLM-019040 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Far upstream element-binding protein 1 |
Protein Synonyms/Alias | FBP; FUSE-binding protein 1; DNA helicase V; hDH V |
Gene Name | FUBP1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 64 | DYGYGGQKRPLEDGD | ubiquitination | [1] | | 76 | DGDQPDAKKVAPQND | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. |
Sequence Annotation | DOMAIN 100 164 KH 1.
DOMAIN 185 251 KH 2.
DOMAIN 275 339 KH 3.
DOMAIN 376 443 KH 4.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 140 140 Phosphoserine.
MOD_RES 153 153 Phosphothreonine.
MOD_RES 630 630 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 644 AA |
Protein Sequence | MADYSTVPPP SSGSAGGGGG GGGGGGVNDA FKDALQRARQ IAAKIGGDAG TSLNSNDYGY 60
GGQKRPLEDG DQPDAKKVAP QNDSFGTQLP PMHQQQRSVM TEEYKVPDGM VGFIIGRGGE 120
QISRIQQESG CKIQIAPDSG GLPERSCMLT GTPESVQSAK RLLDQIVEKG RPAPGFHHGD 180
GPGNAVQEIM IPASKAGLVI GKGGETIKQL QERAGVKMVM IQDGPQNTGA DKPLRITGDP 240
YKVQQAKEMV LELIRDQGGF REVRNEYGSR IGGNEGIDVP IPRFAVGIVI GRNGEMIKKI 300
QNDAGVRIQF KPDDGTTPER IAQITGPPDR CQHAAEIITD LLRSVQAGNP GGPGPGGRGR 360
GRGQGNWNMG PPGGLQEFNF IVPTGKTGLI IGKGGETIKS ISQQSGARIE LQRNPPPNAD 420
PNMKLFTIRG TPQQIDYARQ LIEEKIGGPV NPLGPPVPHG PHGVPGPHGP PGPPGPGTPM 480
GPYNPAPYNP GPPGPAPHGP PAPYAPQGWG NAYPHWQQQA PPDPAKAGTD PNSAAWAAYY 540
AHYYQQQAQP PPAAPAGAPT TTQTNGQGDQ QNPAPAGQVD YTKAWEEYYK KMGQAVPAPT 600
GAPPGGQPDY SAAWAEYYRQ QAAYYAQTSP QGMPQHPPAP QCRFDPASIE LAL 653 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003723; F:RNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0003697; F:single-stranded DNA binding; TAS:ProtInc. GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |