UniProt Accession

 WDR83_HUMAN; Q9BRX9; B2RAF1; Q53FT6 

Genbank Protein ID

 AK223195; AK314164; CH471106; BC005870 

Genbank Nucleotide ID

 BAD96915.1; BAG36848.1; EAW84282.1; AAH05870.1 

Protein Name

 WD repeat domain-containing protein 83 

Protein Synonyms/Alias

 Mitogen-activated protein kinase organizer 1; MAPK organizer 1 

Gene Name

 WDR83 

Gene Synonyms/Alias

 MORG1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	ELPQKRLKTLDCGQG	ubiquitination	[1, 2]
47	CLTCGSDKTLKLWNP	ubiquitination	[2]
50	CGSDKTLKLWNPLRG	ubiquitination	[2]
160	RDGVSSVKVSDHEIL	ubiquitination	[2]
220	STLRLLDKDTGELLG	ubiquitination	[2]
230	GELLGEYKGHKNQEY	ubiquitination	[2]
233	LGEYKGHKNQEYKLD	ubiquitination	[2]
238	GHKNQEYKLDCCLSE	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. 

Sequence Annotation

 REPEAT 23 62 WD 1.
 REPEAT 65 104 WD 2.
 REPEAT 107 146 WD 3.
 REPEAT 151 188 WD 4.
 REPEAT 190 228 WD 5.
 REPEAT 231 272 WD 6.
 REPEAT 275 313 WD 7.  

Keyword

 Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Polymorphism; Reference proteome; Repeat; Spliceosome; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000398; P:mRNA splicing, via spliceosome; IDA:UniProtKB. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.