CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004231
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibrinogen beta chain 
Protein Synonyms/Alias
 Liver regeneration-related protein LRRG036/LRRG043/LRRG189; Fibrinopeptide B; Fibrinogen beta chain 
Gene Name
 Fgb 
Gene Synonyms/Alias
 Ab1-181; Ab1-216; Ac1-581 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
362KYQVSVNKYKGTAGNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. 
Sequence Annotation
 DOMAIN 220 476 Fibrinogen C-terminal.
 REGION 33 35 Beta-chain polymerization, binding distal
 CARBOHYD 382 382 N-linked (GlcNAc...) (Potential).
 DISULFID 211 211 Interchain (with alpha chain) (By
 DISULFID 215 215 Interchain (with gamma chain) (By
 DISULFID 219 304 By similarity.
 DISULFID 229 258 By similarity.
 DISULFID 412 425 By similarity.  
Keyword
 Alternative splicing; Blood coagulation; Coiled coil; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hemostasis; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MRHLWLLLLS VSLVQTQAAT TDSDKVDLSI ARGHRPVDRR KEEPPSLRPA PPPISGGGYR 60
ARPAKVDAGQ KKVERKPPDA GGCVHGDGDM GVLCPTGCEL RQTLLNHERP IKNSIAELNS 120
NINSVSETSS VTFQYLTLLK DMWKKKQAQV KDNENVINEY SSILEDQKLY IDETVNDNIP 180
LNLRVLRSIL EDLRSKIQKL ESDISAQTEY CHTPCTVNCN IPVVSGKECE EIIRKGGETS 240
EMYLIQPDTS SKPYRVYCDM KTENGGWTVI QNRQDGSVDF GRKWDPYKKG FGNIATNEDT 300
KKYCGLPGEY WLGNDKISQL TRIGPTELLI EMEDWKGDKV KAHYGGFTVQ TEANKYQVSV 360
NKYKGTAGNA LMEGASQLVG ENRTMTIHNG MFFSTYDRDN DGWVTTDPRK QCSKEDGGGW 420
WYNRCHAANP NGRYYWGGLY SWDMSKHGTD DGVVWMNWKG SWYSMRRMSM KIRPVFPQQ 479 
Gene Ontology
 GO:0072562; C:blood microparticle; IDA:RGD.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005577; C:fibrinogen complex; IEA:InterPro.
 GO:0031091; C:platelet alpha granule; IEA:Compara.
 GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
 GO:0044320; P:cellular response to leptin stimulus; IEP:RGD.
 GO:0030168; P:platelet activation; IEA:InterPro.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0042060; P:wound healing; TAS:RGD. 
Interpro
 IPR014716; Fibrinogen_a/b/g_C_1.
 IPR014715; Fibrinogen_a/b/g_C_2.
 IPR002181; Fibrinogen_a/b/g_C_dom.
 IPR012290; Fibrinogen_a/b/g_coil_dom.
 IPR020837; Fibrinogen_CS. 
Pfam
 PF08702; Fib_alpha
 PF00147; Fibrinogen_C 
SMART
 SM00186; FBG 
PROSITE
 PS00514; FIBRINOGEN_C_1
 PS51406; FIBRINOGEN_C_2 
PRINTS