UniProt Accession

 A2ARD6_MOUSE; A2ARD6 

Genbank Protein ID

 AL845160; AL845336; CH466519 

Genbank Nucleotide ID

 EDL26852.1 

Protein Name

 Kynureninase 

Protein Synonyms/Alias

 L-kynurenine hydrolase 

Gene Name

 Kynu 

Gene Synonyms/Alias

 mCG_19640 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	LRLDEEDKLSHFRNC	ubiquitination	[1]
51	RNCFYIPKMRDLPSI	ubiquitination	[1]
94	YLEEELDKWAKMGAY	ubiquitination	[1]
97	EELDKWAKMGAYGHD	ubiquitination	[1]
158	KPTPKRHKILLEAKA	ubiquitination	[1]
164	HKILLEAKAFPSDHY	ubiquitination	[1]
186	LHGLDVEKSMRMVKP	ubiquitination	[1]
320	TRFNMDNKLQLIPGA	ubiquitination	[1]
385	SKDNTENKGPIVNII	ubiquitination	[1]
450	NSFHDVYKFIRLLTS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity). 

Sequence Annotation

 REGION 166 169 Pyridoxal phosphate binding (By
 BINDING 138 138 Pyridoxal phosphate; via amide nitrogen
 BINDING 139 139 Pyridoxal phosphate (By similarity).
 BINDING 222 222 Pyridoxal phosphate (By similarity).
 BINDING 251 251 Pyridoxal phosphate (By similarity).
 BINDING 254 254 Pyridoxal phosphate (By similarity).
 BINDING 276 276 Pyridoxal phosphate (By similarity).
 BINDING 306 306 Pyridoxal phosphate (By similarity).
 BINDING 334 334 Pyridoxal phosphate (By similarity).
 MOD_RES 2 2 N-acetylmethionine (By similarity).
 MOD_RES 277 277 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Pyridine nucleotide biosynthesis; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 465 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0030429; F:kynureninase activity; IEA:HAMAP.
 GO:0030170; F:pyridoxal phosphate binding; IEA:HAMAP.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0097053; P:L-kynurenine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0034341; P:response to interferon-gamma; IEA:Compara.
 GO:0034516; P:response to vitamin B6; IEA:Compara.
 GO:0019442; P:tryptophan catabolic process to acetyl-CoA; IEA:Compara.
 GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:Compara. 

Interpro

 IPR000192; Aminotrans_V/Cys_dSase.
 IPR010111; Kynureninase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00266; Aminotran_5 

SMART

  

PROSITE

  

PRINTS