| Tag | Content |
|---|
| CPLM ID | CPLM-000307 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras-specific guanine nucleotide-releasing factor 2 |
Protein Synonyms/Alias | Ras-GRF2; Ras guanine nucleotide exchange factor 2 |
Gene Name | RASGRF2 |
Gene Synonyms/Alias | GRF2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 207 | EDEDPDIKKIKKVQS | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. |
Sequence Annotation | DOMAIN 22 133 PH 1.
DOMAIN 205 234 IQ.
DOMAIN 243 429 DH.
DOMAIN 470 588 PH 2.
DOMAIN 635 756 N-terminal Ras-GEF.
DOMAIN 1002 1234 Ras-GEF.
REGION 744 752 Regulates proteasomal degradation (By
REGION 1099 1128 Responsible of the affinity for
MOD_RES 737 737 Phosphoserine; by CDK5.
MOD_RES 746 746 Phosphoserine. |
Keyword | Calcium; Calmodulin-binding; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Endoplasmic reticulum; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1237 AA |
Protein Sequence | MQKSVRYNEG HALYLAFLAR KEGTKRGFLS KKTAEASRWH EKWFALYQNV LFYFEGEQSC 60
RPAGMYLLEG CSCERTPAPP RAGAGQGGVR DALDKQYYFT VLFGHEGQKP LELRCEEEQD 120
GKEWMEAIHQ ASYADILIER EVLMQKYIHL VQIVETEKIA ANQLRHQLED QDTEIERLKS 180
EIIALNKTKE RMRPYQSNQE DEDPDIKKIK KVQSFMRGWL CRRKWKTIVQ DYICSPHAES 240
MRKRNQIVFT MVEAESEYVH QLYILVNGFL RPLRMAASSK KPPISHDDVS SIFLNSETIM 300
FLHEIFHQGL KARIANWPTL ILADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD 360
KLLKQYEANP ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE 420
ELSRVMHDEV SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGSLIQVP SVERGKLSKV 480
RLGSLSLKKE GERQCFLFTK HFLICTRSSG GKLHLLKTGG VLSLIDCTLI EEPDASDDDS 540
KGSGQVFGHL DFKIVVEPPD AAAFTVVLLA PSRQEKAAWM SDISQCVDNI RCNGLMTIVF 600
EENSKVTVPH MIKSDARLHK DDTDICFSKT LNSCKVPQIR YASVERLLER LTDLRFLSID 660
FLNTFLHTYR IFTTAAVVLG KLSDIYKRPF TSIPVRSLEL FFATSQNNRG EHLVDGKSPR 720
LCRKFSSPPP LAVSRTSSPV RARKLSLTSP LNSKIGALDL TTSSSPTTTT QSPAASPPPH 780
TGQIPLDLSR GLSSPEQSPG TVEENVDNPR VDLCNKLKRS IQKAVLESAP ADRAGVESSP 840
AADTTELSPC RSPSTPRHLR YRQPGGQTAD NAHCSVSPAS AFAIATAAAG HGSPPGFNNT 900
ERTCDKEFII RRTATNRVLN VLRHWVSKHA QDFELNNELK MNVLNLLEEV LRDPDLLPQE 960
RKAAANILRA LSQDDQDDIH LKLEDIIQMT DCMKAECFES LSAMELAEQI TLLDHVIFRS 1020
IPYEEFLGQG WMKLDKNERT PYIMKTSQHF NDMSNLVASQ IMNYADVSSR ANAIEKWVAV 1080
ADICRCLHNY NGVLEITSAL NRSAIYRLKK TWAKVSKQTK ALMDKLQKTV SSEGRFKNLR 1140
ETLKNCNPPA VPYLGMYLTD LAFIEEGTPN FTEEGLVNFS KMRMISHIIR EIRQFQQTSY 1200
RIDHQPKVAQ YLLDKDLIID EDTLYELSLK IEPRLPA 1237 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0097190; P:apoptotic signaling pathway; TAS:Reactome. GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome. GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. GO:0007268; P:synaptic transmission; TAS:Reactome. |
Interpro | |
Pfam | |
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PRINTS | |