CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coagulation factor X 
Protein Synonyms/Alias
  
Gene Name
 F10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
338DIAVLRLKTPITFRMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Disulfide bond; EGF-like domain; Hydrolase; Protease; Reference proteome; Repeat; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MPVTATAVLD HTMGSPVQLS LLCVVLASLL LPGKGVFINR ERANNVLART RRANSFFEEF 60
KKGNLERECM EEICSYEEVR EIFEDDEKTK EYWTKYKDGD QCESSPCQNQ GACRDGIGGY 120
TCTCSEGFEG KNCELFVRKL CRLDNGDCDQ FCREEQNSVV CSCASGYFLG NDGKSCISTA 180
PFPCGKITTG RRKRSVALNT SDSELDLEDA LLDEDFLSPT ENPIELLNLN ETQPERSSDD 240
LVRIVGGREC KDGECPWQAL LINEDNEGFC GGTILNEFYI LTAAHCLHQA RRFKVRVGDR 300
NTEKEEGNEM VHEVDVVIKH NKFQRDTYDY DIAVLRLKTP ITFRMNVAPA CLPQKDWAES 360
TLMTQKTGIV SGFGRTHEKG RQSNILKMLE VPYVDRNTCK LSTSFSITQN MFCAGYEAKL 420
EDACQGDSGG PHVTRFKNTY YVTGIVSWGE GCARKGKYGI YTKVTTFLKW IDRSMKARVG 480
PTAETPRTAG PPN 493 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:InterPro.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0004252; F:serine-type endopeptidase activity; IEA:Compara.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR017857; Coagulation_fac_subgr_Gla_dom.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR000294; GLA_domain.
 IPR012224; Pept_S1A_FX.
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00008; EGF
 PF00594; Gla
 PF00089; Trypsin 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00069; GLA
 SM00020; Tryp_SPc 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS00011; GLA_1
 PS50998; GLA_2
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS
 PR00722; CHYMOTRYPSIN.
 PR00001; GLABLOOD.