| Tag | Content |
|---|
| CPLM ID | CPLM-018357 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Suppressor of cytokine signaling 4 |
Protein Synonyms/Alias | SOCS-4; Suppressor of cytokine signaling 7; SOCS-7 |
Gene Name | SOCS4 |
Gene Synonyms/Alias | SOCS7 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 106 | VGQCFPIKNCSSRHS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. |
Sequence Annotation | DOMAIN 286 381 SH2.
DOMAIN 376 425 SOCS box. |
Keyword | 3D-structure; Complete proteome; Growth regulation; Reference proteome; SH2 domain; Signal transduction inhibitor; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 440 AA |
Protein Sequence | MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV 60
SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 120
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINSKSDE WVSTDLSQTE LRDGQLKRRN 180
MEENINCFSH TNVQPCVITT DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS 240
SRKRNKPKWD LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL 300
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC VFHSPDITGL 360
LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC TTYDGIDALP IPSSMKLYLK 420
EYHYKSKVRV LRIDAPEQQC 440 |
Gene Ontology | GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IDA:UniProtKB. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
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