| Tag | Content |
|---|
| CPLM ID | CPLM-024660 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Plexin-B2 |
Protein Synonyms/Alias | |
Gene Name | Plxnb2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1239 | EREYEKIKSQLEGLE | ubiquitination | [1] | | 1305 | KDVMITGKLDIPESR | ubiquitination | [1] | | 1747 | SNKLLYAKEISTYKK | ubiquitination | [1] | | 1821 | EEDPAAQKMQLAFRL | ubiquitination | [1] | | 1838 | IAAALENKVTDL*** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). |
Sequence Annotation | DOMAIN 20 468 Sema.
DOMAIN 806 895 IPT/TIG 1.
DOMAIN 898 982 IPT/TIG 2.
DOMAIN 986 1095 IPT/TIG 3.
MOD_RES 1248 1248 Phosphoserine.
CARBOHYD 127 127 N-linked (GlcNAc...) (Potential).
CARBOHYD 242 242 N-linked (GlcNAc...) (Potential).
CARBOHYD 393 393 N-linked (GlcNAc...).
CARBOHYD 451 451 N-linked (GlcNAc...) (Potential).
CARBOHYD 798 798 N-linked (GlcNAc...) (Potential).
CARBOHYD 919 919 N-linked (GlcNAc...) (Potential).
CARBOHYD 1053 1053 N-linked (GlcNAc...) (Potential).
CARBOHYD 1072 1072 N-linked (GlcNAc...) (Potential).
DISULFID 78 87 By similarity.
DISULFID 112 120 By similarity.
DISULFID 250 366 By similarity.
DISULFID 266 313 By similarity.
DISULFID 331 353 By similarity.
DISULFID 471 488 By similarity.
DISULFID 477 520 By similarity.
DISULFID 480 497 By similarity.
DISULFID 491 503 By similarity.
DISULFID 557 576 By similarity. |
Keyword | Cell membrane; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1842 AA |
Protein Sequence | MALPLWALTF LGLTGLGLSL RSRKPESFRS ETELNHLAVD EVTGVVYVGA VNALYQLSAD 60
LHVQQHVVTG PFMDNKKCTP PIEASQCHEA VLTDNFNQLL LLDPPGKRLV ECGSLFKGIC 120
ALRAMSNISV RLFYEDGSGE KSFVASNDER VATVGLVTST RPDGERVLFV GKGNGPHDNG 180
IIVSTRLLDR AEGREAFEAY SDHTTFKAGY LSTNTQQFVA AFEDDFYVFF VFNHQDKHPA 240
KNRTLLARMC KDDPSYYSYV EMDLQCQDPS DPQDSAFGTC LAASVATSGA GRALYAVFSR 300
DGRSTGGPGA GLCVFPLDKV REKIEANRNA CYTGAREAGR TIFYKPFHGE IQCGGHLIGA 360
SESFPCGSEH LPYPLGSRDG LVATAVLHRG GLNLTAVTVT AENDHTVAFL GTSDGRILKV 420
YLAPDGTSAE YGSIPVDINK KIKQDLALSG NLSSLYAMTQ DKVFRLPVQE CLSYVTCAQC 480
RDSQDPYCGW CVIEGRCTRK SECSRAEETG HWLWSREKSC VAITDAFPQN MSRRAQGEVR 540
LSVSPLPTLT EDDELLCLFG DSPPHPARVE DDTVICNSPS SIPSTPPGQD HVDVSIQLLL 600
KSGSVFLTSH QYPFYDCREA MSLVENLPCI SCASNRWTCQ WDLQYYECRE ASPNPEEGII 660
RAHMEDNCPQ FLAPDPLVIP MNHETEVTFQ GKNLETVKVS SLYVGSELLN FEETVTMHES 720
DTFSFRTPKL SHDGNETLPL HLYVKSFGKN IDSKLQVTLY NCSFGRSDCS LCLAADPAYR 780
CVWCRGQNRC VYEALCSNVT SECPPPVITR IQPETGPLGG GILVTIHGSN LGVKADDVKK 840
ITVAGQNCAF EPRGYSVSTR IVCAIEASEM PFTGGIEVDV NGKLGHSPPH VQFTYQQPQP 900
LSVEPRQGPQ AGGTTLTING THLDTGSKED VRVTLNDVPC EVTKFGAQLQ CVTGQQLAPG 960
QVTLEIYYGG SRVPSPGISF TYCENPMIRA FEPLRSFVSG GRSINVTGQG FSLIQKFAMV 1020
VIAEPLRSWR RRRREAGALE RVTVEGMEYV FYNDTKVVFL SPAVPEEPEA YNLTVLIRMD 1080
GHCAPLRTEA GVFEYVADPT FENFTGGVKK QVNKLIHARG TNLNKAMTLE EAEAFVGAER 1140
CIMKTLTETD LYCEPPEVQP PPKRRQKRDT AHNLPEFIVK FGSREWVLGR VEYDTRASDV 1200
PLSLILPLVM VPMVFIIVVS IYCYWRKSQQ AEREYEKIKS QLEGLEESVR DRCKKEFTDL 1260
MIEMEDQTND VHEAGIPTLD YKTYTDRVFF LPSKDGDKDV MITGKLDIPE SRRPIVEQAL 1320
YQFSNLLNSK SFLINFIHTL ENQREFSARA KVYFASLLTV ALHGKLEYYT DIMRTLFLEL 1380
MEQYVVAKNP KLMLRRSETV VERMLSNWMS ICLYQYLKDS AGEPLYKLFK AIKHQVEKGP 1440
VDAVQKKAKY TLNDTGLLGD DVEYAPLTVS VIVQDEGIDA IPVKVLNCDT ISQVKEKIID 1500
QVYRTQPCSC WPKPDSVVLE WRPGSTAQIL SDLDLTSQRE GRWKRINTLM HYNVRDGATL 1560
ILSKVGVSQQ PEDSQQDLPG ERHALLEEEN RVWHLVRPTD EVDEGKSKRG SMKEKERTKA 1620
ITEIYLTRLL SVKGTLQQFV DNFFQSVLAP GHAVPPAVKY FFDFLDEQAE KHDIRDEDTI 1680
HIWKTNSLPL RFWVNILKNP HFIFDVHVHE VVDASLSVIA QTFMDACTRT EHKLSRDSPS 1740
NKLLYAKEIS TYKKMVEDYY KGIRQMVQVS DQDMNTHLAE ISRAHTDSLN TLVALHQLYQ 1800
YTQKYYDEII NALEEDPAAQ KMQLAFRLQQ IAAALENKVT DL 1842 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. GO:0005622; C:intracellular; IEA:InterPro. GO:0017154; F:semaphorin receptor activity; IMP:UniProtKB. GO:0007420; P:brain development; IMP:UniProtKB. GO:0001843; P:neural tube closure; IMP:UniProtKB. GO:0007405; P:neuroblast proliferation; IMP:UniProtKB. GO:0050772; P:positive regulation of axonogenesis; IGI:MGI. GO:0008360; P:regulation of cell shape; IMP:UniProtKB. GO:2001222; P:regulation of neuron migration; IMP:UniProtKB. GO:0001932; P:regulation of protein phosphorylation; IMP:UniProtKB. GO:0032319; P:regulation of Rho GTPase activity; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |